Trial reportDepression and anxiety2022
The effects of the Unified Protocol and Unified Protocol skills on loneliness in the COVID-19 pandemic.
Trial report in Depression and anxiety, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Longitudinal associations between loneliness and outcomes of Common Mental Disorders (CMDs): A systematic review and meta-analysis.BMC medicine · 2026Pooled it
- The effects of the Unified Protocol and Unified Protocol skills on loneliness in the COVID-19 pandemic.Depression and anxiety · 2022Trial
- Developing loneliness interventions for people with personality disorders: A call to action.Annals of the New York Academy of Sciences · 2025Review
- Interventions in ambulatory healthcare settings to reduce social isolation among adults aged 18-64: a systematic review.BJGP open · 2024Article
- A Review of Transdiagnostic Mechanisms in Cognitive Behavior Therapy.The Psychiatric clinics of North America · 2024Review
- Skill Use Mediates the Within-Person Effect of the Alliance on Session-to-Session Changes in Anxiety and Depression in the Unified Protocol.Journal of mood and anxiety disorders · 2024Article
- Resilience, Coping, and the Covid-19 Pandemic Across the Globe - an Update: What Have we Learned?Clinical neuropsychiatry · 2023Review
- Not one thing at a time: When concomitant multiple stressors produce a transdiagnostic clinical picture.World journal of psychiatry · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLoneliness is a significant public health concern with no established first-line intervention although modular, transdiagnostic, cognitive-behavioral interventions, such as the Unified Protocol (UP), are promising candidates. The UP contains skill modules to target anxiety, depression, and related conditions, although it is unclear if the UP can reduce loneliness and if UP skill use contributes to these reductions.
methodsUsing data from the first-stage randomization of a sequential multiple assignment randomized trial, we tested whether the UP led to reductions in loneliness and whether specific dimensions of UP skill use predicted session-to-session changes in loneliness. Participants (N = 70; M
resultsLoneliness significantly decreased during treatment with the UP. Using more UP skills than one's personal average, but not frequency of skill use, predicted session-to-session decreases in loneliness.
conclusionsTherapists may be encouraged to guide patients toward using a large quantity of different skills to specifically address loneliness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.