ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2022
Longitudinal changes in ventricular size and function are associated with death and transplantation late after the Fontan operation.
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Measuring atrioventricular valve regurgitation in Fontan patients using cardiovascular magnetic resonance imaging and the association with clinical outcomes: A FORCE Study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026Article
- Multimodal Imaging from Fetal to Adult Life: A Comprehensive Approach to Hypoplastic Left Heart Syndrome (HLHS).Journal of cardiovascular development and disease · 2025Review
- Longitudinal changes in ventricular function and atrioventricular valve failure following cardiac morphology after Fontan procedure.Journal of thoracic disease · 2025Article
- Impact of cardiovascular magnetic resonance in single ventricle physiology: a narrative review.Cardiovascular diagnosis and therapy · 2024Review
- Right Ventricular Remodeling and Function in Hypoplastic Left Heart Syndrome.JACC. Advances · 2024Review
- Central Venous Waveform Patterns in the Fontan Circulation Independently Contribute to the Prediction of Composite Survival.Pediatric cardiology · 2024Review
- Application of Principal Component Analysis to Heterogenous Fontan Registry Data Identifies Independent Contributing Factors to Decline.medRxiv : the preprint server for health sciences · 2024Article
- Discordance interpretation of left ventricular size between echocardiography and cardiac magnetic resonance in pediatric patients with aortic/mitral regurgitation.The international journal of cardiovascular imaging · 2024Article
- Significantly elevated hepatic extracellular volume in adult patients with a Fontan circulation and its correlation with impaired functional capacity.The international journal of cardiovascular imaging · 2024Article
- Cardiovascular magnetic resonance reference values of right ventricular volumetric variables in patients with hypoplastic left heart syndrome.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- The neo-aortic valve in patients with hypoplastic left heart syndrome is largely preserved: a serial follow-up CMR study.Frontiers in cardiovascular medicine · 2024Article
- Ventricular dyssynchrony late after the Fontan operation is associated with decreased survival.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- Single Ventricular Torsional Mechanics After Fontan Palliation and Their Impact on Outcomes.JACC. Advances · 2023Article
- The clinical role of two-dimensional phase-contrast flow measurements through cardiac magnetic resonance in Fontan patients.Annals of pediatric cardiologyArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCross-sectional studies have reported that ventricular dilation and dysfunction are associated with adverse clinical outcome in Fontan patients; however, longitudinal changes and their relationship with outcome are not known.
methodsThis was a single-center retrospective analysis of Fontan patients with at least 2 cardiovascular magnetic resonance (CMR) scans without intervening interventions. Serial measures of end-diastolic volume index (EDVI), end-systolic volume index (ESVI), ejection fraction (EF), indexed mass (mass
resultsData from 156 patients were analyzed with a mean age at 1st CMR of 17.8 ± 9.6 years. 490 CMRs were included with median of 3 CMRs/patient (range 2-9). On regression analysis with mixed effects models, volumes and ESWS increased, while mass, mass-to-volume ratio, and EF decreased over time. With a median follow-up of 10.2 years, 14% met the composite outcome. Those with the composite outcome had a greater increase in EDVI compared to those without (4.7 vs. 0.8 ml/BSA
conclusionsVentricles in the Fontan circulation exhibit a steady decline in performance with an increase in EDVI, ESVI, and ESWS, and decrease in EF, mass index, and mass-to-volume ratio. Those with death or need for heart transplantation have a faster increase in EDVI. Patients with rapid increase in EDVI (> 5 ml/BSA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.