Evidence map›Paper›PMID 36372864›Full record

ArticleDigestive diseases and sciences2023

Delivery of Fecal Material to Terminal Ileum Is Associated with Long-Term Success of Fecal Microbiota Transplantation.

Alexa R Weingarden, Olivia Treiger, Lauren Ulsh, Berkeley Limketkai, David Goldenberg, Philip Okafor, Irene Sonu, Neil Stollman, Leila Neshatian

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Alexa R WeingardenDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford University, 420 Broadway Street Pavilion D, 2nd Floor, Redwood City, CA, 94063, USA. aweingar@stanford.edu.ORCID http://orcid.org/0000-0002-1567-1320
Olivia TreigerDivision of Gastroenterology, Alta Bates Summit Medical Center, East Bay Center for Digestive Health, 300 Frank H Ogawa Plaza #450, Oakland, CA, 94612, USA.
Lauren UlshDepartment of Medicine, Stanford University, 300 Pasteur Drive, S102, Stanford, CA, 94304, USA.
Berkeley LimketkaiDivision of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Westwood Digestive Diseases, 100 Medical Plaza, Suite 345, Los Angeles, CA, 90024, USA.
David GoldenbergDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford University, 420 Broadway Street Pavilion D, 2nd Floor, Redwood City, CA, 94063, USA.
Philip OkaforDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford University, 420 Broadway Street Pavilion D, 2nd Floor, Redwood City, CA, 94063, USA.
Irene SonuDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford University, 420 Broadway Street Pavilion D, 2nd Floor, Redwood City, CA, 94063, USA.
Neil StollmanDepartment of Medicine, Stanford University, 300 Pasteur Drive, S102, Stanford, CA, 94304, USA.
Leila NeshatianDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford University, 420 Broadway Street Pavilion D, 2nd Floor, Redwood City, CA, 94063, USA.
Stanford University · USAlta Bates Summit Medical Center · USStanford Medicine · USUniversity of California, Los Angeles · US

Funding

TRAINING GRANT IN ACADEMIC GASTROENTEROLOGYT32DK007056 · NIDDK · STANFORD UNIVERSITY · PI Natalie J. Torok · 1986 to 2026
$6.5M
NIDDK NIH HHS T32 DK007056
6 · The paper itself

Abstract

backgroundFecal microbiota transplantation (FMT) is a highly effective treatment for recurrent Clostridioides difficile infection (CDI). However, 10-20% of patients still fail to recover following FMT. There is a need to understand why these failures occur and if there are modifiable factors that can be addressed by clinicians performing FMT.

aimsWe sought to identify factors related to the FMT procedure itself which could impact FMT outcomes. We also aimed to identify patient demographics which might be associated with FMT outcomes and whether any factors were associated with early FMT failure compared to late CDI recurrence.

methodsWe performed a retrospective multicenter cohort analysis of FMT procedures between October 2005 and November 2020. We collected data on patient demographics, details of the FMT procedure, and procedure outcomes. Using univariate and multivariate regression, we evaluated whether these factors were associated with long-term FMT success, early FMT failure (less than 60 days following procedure), or late CDI recurrence (more than 60 days following procedure).

resultsLong-term success of FMT was strongly correlated with any delivery of stool to the terminal ileum (Odds Ratio [OR] 4.83, 95% confidence interval [CI] 1.359-17.167) and underlying neurologic disease (OR 8.012, 95% CI 1.041-61.684). Lower bowel prep quality was significantly associated with both early FMT failure (p = 0.034) and late CDI recurrence (p = 0.050).

conclusionsDelivery of stool to the terminal ileum is significantly associated with long-term success following FMT. This is a relatively safe practice which could easily be incorporated into the standard of care for colonoscopic FMT.

Indexed as

Clostridioides difficileClostridium InfectionsFecal Microbiota TransplantationFecesHumansIleumRecurrenceTreatment OutcomeClinical factors in failure of fecal microbiota transplantationClostridioides difficile infectionFecal microbiota transplantation

Identifiers

PMID36372864
PMCPMC10994768
OpenAlexW4308958105

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.