Evidence map›Paper›PMID 36372857›Full record

ArticleClinical and experimental medicine2023

Intermediate monocytes expansion and homing markers expression in COVID-19 patients associate with kidney dysfunction.

Chiara Dentone, Daniela Fenoglio, Alessia Parodi, Tiziana Altosole, Antonio Di Biagio, Federica Bozzano, Giorgia Nasi, Antonio Vena, Marina Fabbi, Francesca Ferrera and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Induction of dysfunctional CD14Frontiers in immunology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Chiara Dentone *Division of Infectious Diseases, IRCCS Ospedale Policlinico San Martino - IRCCS, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy. chiaradentone@libero.it.ORCID https://orcid.org/0000-0002-9096-5812
Daniela Fenoglio *Biotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Alessia Parodi *Biotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Tiziana AltosoleCentre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.
Antonio Di BiagioDivision of Infectious Diseases, IRCCS Ospedale Policlinico San Martino - IRCCS, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy.
Federica BozzanoCentre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.
Giorgia NasiBiotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Antonio VenaDepartment of Health Sciences, University of Genoa, 16132, Genoa, Italy.
Marina FabbiBiotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Francesca FerreraCentre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.
Bianca BruzzoneHygiene Unit, IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Mauro GiacominiDepartment of Informatics Bioengineering, Robotics, and Systems Engineering (DIBRIS), University of Genoa, 16145, Genoa, Italy.
Daniele Roberto GiacobbeDivision of Infectious Diseases, IRCCS Ospedale Policlinico San Martino - IRCCS, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy.
Paolo PelosiDepartment of Surgical Sciences and Integrated Diagnostics, University of Genoa, 16132, Genoa, Italy.
Andrea De MariaDivision of Infectious Diseases, IRCCS Ospedale Policlinico San Martino - IRCCS, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy.
Matteo BassettiDivision of Infectious Diseases, IRCCS Ospedale Policlinico San Martino - IRCCS, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy.
Raffaele De PalmaCentre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.
Gilberto FilaciBiotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with severe SARS-CoV-2 infection have an overwhelming inflammatory response characterized by remarkable organs monocyte infiltration. We performed an immunophenotypic analysis on circulating monocytes in 19 COVID-19 patients in comparison with 11 naïve HIV-1 patients and 10 healthy subjects. Reduced frequency of classical monocytes and increased frequency of intermediate monocytes characterized COVID-19 patients with respect to both HIV naïve patients and healthy subjects. Intensity of C-C motif chemokine receptor 2 (CCR2) monocyte expression highly correlated with parameters of kidney dysfunction. Our data indicate that highly activated monocytes of COVID-19 patients may be pathogenically associated with the development of renal disease.

Indexed as

COVID-19MonocytesHumansKidneyReceptors, CCR2SARS-CoV-2Receptors, CCR2C–C motif chemokine receptor 2Covid-19Innate immunityMonocytesSARS-CoV-2

Identifiers

PMID36372857
PMCPMC9660192

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.