Evidence map›Paper›PMID 36372395›Full record

ArticleInfection control and hospital epidemiology2023

Clinical impact of healthcare-associated respiratory syncytial virus in hospitalized adults.

Alexandra Hill-Ricciuti, Edward E Walsh, William G Greendyke, Yoonyoung Choi, Angela Barrett, Luis Alba, Angela R Branche, Ann R Falsey, Matthew Phillips, Lyn Finelli and 1 more

Open access · hybridFull text readComparative StudyMulticenter Study
In one paragraph

Article in Infection control and hospital epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  7. Article
  8. Severe respiratory syncytial virus disease.Journal of intensive medicine · 2024
    Review
  9. In Support of Universal Admission Testing for SARS-CoV-2 During Significant Community Transmission.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Alexandra Hill-RicciutiDepartment of Pediatrics, Columbia University Irving Medical Center, New York, New York.ORCID 0000-0003-2411-2712
Edward E WalshDepartment of Medicine, University of Rochester, Rochester, New York.
William G GreendykeDepartment of Medicine, Columbia University Irving Medical Center, New York, New York.
Yoonyoung ChoiCenter for Observational and Real-World Evidence, Merck & Company, Kenilworth, New Jersey.
Angela BarrettDepartment of Pediatrics, Columbia University Irving Medical Center, New York, New York.
Luis AlbaDepartment of Pediatrics, Columbia University Irving Medical Center, New York, New York.
Angela R BrancheDepartment of Medicine, University of Rochester, Rochester, New York.
Ann R FalseyDepartment of Medicine, University of Rochester, Rochester, New York.
Matthew PhillipsCenter for Observational and Real-World Evidence, Merck & Company, Kenilworth, New Jersey.
Lyn FinelliCenter for Observational and Real-World Evidence, Merck & Company, Kenilworth, New Jersey.
Lisa SaimanDepartment of Pediatrics, Columbia University Irving Medical Center, New York, New York.ORCID 0000-0002-7231-8451
Columbia University Irving Medical Center · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USNewYork–Presbyterian Hospital · USRochester General Hospital · USUniversity of Rochester · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe the clinical impact of healthcare-associated (HA) respiratory syncytial virus (RSV) in hospitalized adults.

designRetrospective cohort study within a prospective, population-based, surveillance study of RSV-infected hospitalized adults during 3 respiratory seasons: October 2017-April 2018, October 2018-April 2019, and October 2019-March 2020.

settingThe study was conducted in 2 academically affiliated medical centers. PATIENTS: Each HA-RSV patient (in whom RSV was detected by PCR test ≥4 days after hospital admission) was matched (age, sex, season) with 2 community-onset (CO) RSV patients (in whom RSV was detected ≤3 days of admission).

methodsRisk factors and outcomes were compared among HA-RSV versus CO-RSV patients using conditional logistic regression. Escalation of respiratory support associated with RSV detection (day 0) from day -2 to day +4 was explored among HA-RSV patients.

resultsIn total, 84 HA-RSV patients were matched to 160 CO-RSV patients. In HA-RSV patients, chronic kidney disease was more common, while chronic respiratory conditions and obesity were less common. HA-RSV patients were not more likely to be admitted to an ICU or require mechanical ventilation, but they more often required a higher level of care at discharge compared with CO-RSV patients (44% vs 14%, respectively). Also, 29% of evaluable HA-RSV patients required respiratory support escalation; these patients were older and more likely to have respiratory comorbidities, to have been admitted to intensive care, and to die during hospitalization.

conclusionsHA-RSV in adults may be associated with escalation in respiratory support and an increased level of support in living situation at discharge. Infection prevention and control strategies and RSV vaccination of high-risk adults could mitigate the risk of HA-RSV.

Indexed as

Cross InfectionHospitalizationRespiratory Syncytial VirusesRespiratory Syncytial Virus InfectionsAdultAgedComorbidityFemaleHumansLogistic ModelsMaleMiddle AgedObesityPatient DischargeProspective StudiesRenal Insufficiency, Chronic

Identifiers

PMID36372395
PMCPMC10015267
OpenAlexW4308894010

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read49
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.