Evidence map›Paper›PMID 36372251›Full record

Trial reportAmerican heart journal2023

Physical activity and relationship to physical function, quality of life, and cognitive function in older patients with acute decompensated heart failure.

Michael Benjamin Nelson, Eric J Shiroma, Dalane W Kitzman, Pamela W Duncan, Gordon R Reeves, David J Whellan, Robert J Mentz, Haiying Chen, Amy M Pastva

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in American heart journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02196038 (REHAB-HF), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02196038 nacompletednot on this map

REHAB-HF: A Trial of Rehabilitation Therapy in Older Acute Heart Failure Patients

TypeinterventionalSponsorWake Forest University Health SciencesRan2014 to 2020Enrolled349ConditionsAcute Decompensated Heart FailureArmsmulti-domain rehabilitation intervention, Attention Control
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michael Benjamin NelsonDepartment of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
Eric J ShiromaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, MD.
Dalane W KitzmanDepartment of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC; Department of Internal Medicine, Sections on Geriatrics, Wake Forest School of Medicine, Winston-Salem, NC.
Pamela W DuncanDepartment of Neurology, Wake Forest School of Medicine, Winston-Salem, NC.
Gordon R ReevesNovant Health Heart and Vascular Institute, Charlotte, NC.
David J WhellanDepartment of Medicine, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.
Robert J MentzDepartment of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC.
Haiying ChenDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC.
Amy M PastvaDepartment of Orthopaedic Surgery, Physical Therapy Division, Duke University School of Medicine, Durham, NC. Electronic address: amy.pastva@duke.edu.

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6M
TRANSFORM-HF CCCU01HL125511 · NHLBI · YALE UNIVERSITY · PI MENTZ, ROBERT JOHN, VELAZQUEZ, ERIC J · 2017 to 2021
$7.7M
REHAB-HF: A Trial of Rehabilitation Therapy in Older Acute Heart Failure PatientsR01AG045551 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2014 to 2018
$6.8M
Pepper OAIC Coordinating CenterU24AG059624 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DALANE W KITZMAN · 2018 to 2026
$6.0M
Exercise Intolerance in Older HFPEF PatientsR01AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2001 to 2019
$5.2M
Exercise Intolerance in Elderly Diastolic Heart FailureR37AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2005 to 2013
$3.4M
NCATS NIH HHS UL1 TR001420NHLBI NIH HHS U01 HL125511NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG028716NIA NIH HHS R01 AG018915NIA NIH HHS R01 AG045551NIA NIH HHS R37 AG018915NIA NIH HHS U24 AG059624
6 · The paper itself

Abstract

backgroundVolitional physical activity level is predictive of a variety of health outcomes, but has not been examined in patients recently hospitalized for acute decompensated HF (ADHF).

methodsTen to 14 days after index hospitalization for ADHF, 93 participants wore a wrist-mounted triaxial accelerometer (ActiGraph GT3X+) to objectively quantify sedentary behavior, light physical activity, and moderate-to-vigorous physical activity. Levels were compared to 2 groups of age-matched NHANES participants: healthy and chronic, stable HF. The relationship between physical activity levels and physical function [Short Physical Performance Battery (SPPB)], HF-specific quality-of-life (QOL) [Kansas City Cardiomyopathy Questionnaire (KCCQ)], and cognition [Montreal Cognitive Assessment (MOCA)] were examined.

resultsADHF participants accumulated a median 1,008 (IQR 896, 1,109) minutes of sedentary time, 88 (57, 139) minutes of light physical activity, and 10 (6, 25) minutes of moderate-to-vigorous physical activity per day. Sedentary time, light physical activity, or moderate-to-vigorous activity did not differ by sex or EF subtype. ADHF participants spent only 9% of awake time nonsedentary, compared to 34% and 27% for healthy adults and adults with chronic, stable HF, respectively. Among ADHF participants, SPPB, KCCQ, and MOCA scores did not differ among quartiles of total physical activity.

conclusionsOlder patients recently hospitalized for ADHF have very low levels of physical activity and high levels of sedentary time, both of which may be potential targets for interventions in this high-risk population. Physical activity level was not significantly associated with objectively measured physical function, QOL, or cognition, suggesting that this measure provides independent information regarding the patient experience of living with HF.

trial registrationNCT02196038, https://clinicaltrials.gov/ct2/show/NCT02196038.

Indexed as

Heart FailureQuality of LifeAdultAgedCognitionExerciseFemaleHumansMaleNutrition Surveys

Identifiers

PMID36372251
PMCPMC9840656

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.