Evidence map›Paper›PMID 36371828›Full record

ReviewCurrent opinion in neurobiology2022

Glia as antigen-presenting cells in the central nervous system.

Pearl A Sutter, Stephen J Crocker

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. The emerging role of T cells in depression.Frontiers in psychiatry · 2026
    Review
  4. Review
  5. CXCL10CNS neuroscience & therapeutics · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Astrocytes and Tinnitus.Brain sciences · 2024
    Review
  11. Article
  12. Microglia and Systemic Immunity.Advances in neurobiology · 2024
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Pearl A SutterDepartments of Neuroscience, University of Connecticut School of Medicine, Farmington, CT, USA.
Stephen J CrockerDepartments of Neuroscience, University of Connecticut School of Medicine, Farmington, CT, USA. Electronic address: crocker@uchc.edu.
University of Connecticut · US

Funding

The role of microglia as antigen presenting cells in Globoid Cell LeukodystrophyF30NS129238 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI SUTTER, PEARL A · 2022 to 2025
$195k
NINDS NIH HHS F30 NS129238
6 · The paper itself

Abstract

The contribution of the cells within the central nervous system (CNS) toward adaptive immune responses is emerging and incompletely understood. Recent findings indicate important functional interactions between T-cells and glial cells within the CNS that may contribute to disease and neuropathology through antigen presentation. Although glia are not classically considered antigen-presenting cell (APC) types, there is growing evidence indicating that glial antigen presentation plays an important role in several neurological diseases. This review discusses these findings which incriminate microglia, astrocytes, and oligodendrocyte lineage cells as CNS-resident APC types with implications for understanding disease.

Indexed as

Central Nervous SystemNeurogliaAntigen-Presenting CellsAstrocytesMicroglia

Identifiers

PMID36371828
PMCPMC10183975
OpenAlexW4309093305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.