Evidence map›Paper›PMID 36371816›Full record

ArticleNeurobiology of aging2023

Plasma neurofilament light as blood marker for poor brain white matter integrity among middle-aged urban adults.

May A Beydoun, Nicole Noren Hooten, Jordan Weiss, Ana I Maldonado, Hind A Beydoun, Leslie I Katzel, Christos Davatzikos, Rao P Gullapalli, Stephen L Seliger, Guray Erus and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

May A BeydounLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. Electronic address: baydounm@mail.nih.gov.
Nicole Noren HootenLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Jordan WeissStanford Center on Longevity, Stanford University, Stanford, CA USA.
Ana I MaldonadoLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA; Department of Psychology, University of Maryland, Catonsville, MD, USA.
Hind A BeydounDepartment of Research Programs, Fort Belvoir Community Hospital, Fort Belvoir, VA, USA.
Leslie I KatzelDivision of Gerontology, Geriatrics, and Palliative Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Division of Gerontology & Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Christos DavatzikosArtificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rao P GullapalliDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Stephen L SeligerDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Guray ErusArtificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michele K EvansLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Shari R WaldsteinDepartment of Psychology, University of Maryland, Catonsville, MD, USA; Division of Gerontology, Geriatrics, and Palliative Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Division of Gerontology & Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
University of Maryland, Baltimore · USNational Institute on Aging · USIntel (United States) · USNational Institutes of Health · USAlexander T. Augusta Military Medical Center · USStanford University · US

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Age-associated cognitive changes in community dwelling adultsZIAAG000195 · NIA · NATIONAL INSTITUTE ON AGING · PI ZONDERMAN, ALAN B · 2009 to 2019
$9.3M
Healthy Aging Neighborhoods of Diversity Across LifespanZ01AG000513 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2001 to 2008
$6.8M
HANDLS Scan Substudy: Race, Socioeconomic status, and the BrainR01AG034161 · NIA · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI WALDSTEIN, SHARI · 2009 to 2013
$2.8M
Biomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9M
Intramural NIH HHS Z01 AG000513Intramural NIH HHS ZIA AG000195NIA NIH HHS P30 AG028747NIA NIH HHS R01 AG034161NIH HHS S10 OD023495
6 · The paper itself

Abstract

Plasma neurofilament light chain (NfL)'s link to dementia may be mediated through white matter integrity (WMI). In this study, we examined plasma NfL's relationships with diffusion tensor magnetic resonance imaging markers: global and cortical white matter fractional anisotropy (FA) and trace (TR). Plasma NfL measurements at 2 times (v

Indexed as

White MatterAnisotropyBiomarkersBrainDiffusion Tensor ImagingHumansIntermediate FilamentsMaleMiddle AgedBiomarkersagingbrain magnetic resonance imagingNeurofilament Light Chainwhite matter integrity

Identifiers

PMID36371816
PMCPMC9733693
OpenAlexW4306957832

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.