Evidence map›Paper›PMID 36371755›Full record

ArticleCellular and molecular life sciences : CMLS2022

Rnf20 inhibition enhances immunotherapy by improving regulatory T cell generation.

Xiangqian Luo, Lihua Mo, Xinxin Wang, Shuang Zhang, Huazhen Liu, Gaohui Wu, Qinmiao Huang, Dabo Liu, Pingchang Yang

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiangqian Luo *Department of Pediatric Otolaryngology, Shenzhen Hospital, Southern Medial University, 1333 Xinhu Road, Shenzhen, 518055, China.
Lihua Mo *Department of Pediatric Otolaryngology, Shenzhen Hospital, Southern Medial University, 1333 Xinhu Road, Shenzhen, 518055, China.
Xinxin Wang *Guangdong Provincial Regional Disease Key Laboratory, Room A7-509, 1066 Xueyuan Blvd, Shenzhen, 518055, China.
Shuang ZhangGuangdong Provincial Regional Disease Key Laboratory, Room A7-509, 1066 Xueyuan Blvd, Shenzhen, 518055, China.
Huazhen LiuGuangdong Provincial Regional Disease Key Laboratory, Room A7-509, 1066 Xueyuan Blvd, Shenzhen, 518055, China.
Gaohui WuDepartment of Respirology, Third Affiliated Hospital of Shenzhen University, Room A7-509, 1066 Xueyuan Blvd, Shenzhen, 518055, China.
Qinmiao HuangDepartment of Respirology, Third Affiliated Hospital of Shenzhen University, Room A7-509, 1066 Xueyuan Blvd, Shenzhen, 518055, China. hqmwwb@163.com.
Dabo LiuDepartment of Pediatric Otolaryngology, Shenzhen Hospital, Southern Medial University, 1333 Xinhu Road, Shenzhen, 518055, China. dbliu@126.com.
Pingchang YangGuangdong Provincial Regional Disease Key Laboratory, Room A7-509, 1066 Xueyuan Blvd, Shenzhen, 518055, China. pcy2356@szu.edu.cn.ORCID http://orcid.org/0000-0003-2137-2105
Shenzhen University · CNSouthern Medical University Shenzhen Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAllergic disorders are common all over the world. The pathogenesis of allergy is unclear. Therapies for allergic disorders require improvement. Endoplasmic reticulum (ER) stress is one of the factors influencing immune response. The purpose of this study is to improve the effectiveness of immunotherapy for experimental respiratory allergy by targeting the ER stress signal pathway.

methodsCommitted CD4

resultsER stress was detected in antigen-specific CD4

conclusionsER stress can be detected in CD4

Indexed as

Rhinitis, AllergicT-Lymphocytes, RegulatoryAnimalsImmunotherapyMiceOvalbuminReceptors, Antigen, T-CellUbiquitin-Protein LigasesOvalbuminReceptors, Antigen, T-CellRNF20 protein, mouseUbiquitin-Protein LigasesAllergyCD4 T cellEndoplasmic reticulum stressEnvironmental pollutantImmune regulatory cell

Identifiers

PMID36371755
PMCPMC11802951
OpenAlexW4308857227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.