SynthesisNature communications2022
The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria.
Synthesis in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 30 citations in OpenAlex.
- Hemozoin as a Diagnostic Biomarker: A Scoping Review of Next-Generation Malaria Detection Technologies.Biosensors · 2026Review
- Severe Malaria in Angola: The Clinical Profile and Disease Outcome Among Adults from a Low-Endemic Area.Biomedicines · 2024Article
- Noninvasive in vivo photoacoustic detection of malaria with Cytophone in Cameroon.Nature communications · 2024Article
- Neutrophils versus Protozoan Parasites:Microorganisms · 2024Review
- The association of intraleucocytic malaria pigment and disease severity in Papua New Guinean children with severe P. falciparum malaria.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2023Article
- Severe falciparum malaria in pregnancy in Southeast Asia: a multi-centre retrospective cohort study.BMC medicine · 2023Article
- Severe malaria.Malaria journal · 2022Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 5 countries.
Funding
Abstract
Severe falciparum malaria is a major cause of death in tropical countries, particularly in African children. Rapid and accurate diagnosis and prognostic assessment are critical to clinical management. In 6027 prospectively studied patients diagnosed with severe malaria we assess the prognostic value of peripheral blood film counts of malaria pigment containing polymorphonuclear leukocytes (PMNs) and monocytes. We combine these results with previously published data and show, in an individual patient data meta-analysis (n = 32,035), that the proportion of pigment containing PMNs is predictive of in-hospital mortality. In African children the proportion of pigment containing PMNs helps distinguish severe malaria from other life-threatening febrile illnesses, and it adds to the prognostic assessment from simple bedside examination, and to the conventional malaria parasite count. Microscopy assessment of pigment containing PMNs is simple and rapid, and should be performed in all patients hospitalised with suspected severe malaria.
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Registered trials
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