Evidence map›Paper›PMID 36371344›Full record

ArticleStem cell research & therapy2022

Human umbilical cord mesenchymal stromal cell-derived exosomes protect against MCD-induced NASH in a mouse model.

Ying Shi, Xiaoguang Yang, Shuyue Wang, Yulun Wu, Lihua Zheng, Yufang Tang, Yanhang Gao, Junqi Niu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. [Mesenchymal stem cell-derived exosomes: a new hope for metabolic-associated fatty liver disease].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
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  10. Stem cell extracellular vesicles for neuropsychiatric disorders and translation.Extracellular vesicles and circulating nucleic acids · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ying ShiHepatology Department, First Hospital of Jilin University, No. 1, Xinmin Street, Changchun, 130000, Jilin, People's Republic of China.
Xiaoguang YangNational Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 2555 JingYue Street, Changchun, 130000, Jilin, People's Republic of China.
Shuyue WangNational Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 2555 JingYue Street, Changchun, 130000, Jilin, People's Republic of China.
Yulun WuNational Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 2555 JingYue Street, Changchun, 130000, Jilin, People's Republic of China.
Lihua ZhengNational Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 2555 JingYue Street, Changchun, 130000, Jilin, People's Republic of China.
Yufang TangBiomedical Laboratory Center of Wish Vocational Training School, Beihu Science and Technology Zone, Changchun, 130012, Jilin, People's Republic of China.
Yanhang GaoHepatology Department, First Hospital of Jilin University, No. 1, Xinmin Street, Changchun, 130000, Jilin, People's Republic of China. yanhang@mail.jlu.edu.cn.
Junqi NiuHepatology Department, First Hospital of Jilin University, No. 1, Xinmin Street, Changchun, 130000, Jilin, People's Republic of China. junqiniu@jlu.edu.cn.
Northeast Normal University · CNFirst Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsHuman umbilical cord mesenchymal stem cells (hUC-MSCs) are increasingly being studied in clinical trials of end-stage liver disease because of their good tissue repair and anti-inflammatory effects. hUC-MSC exosomes are vesicles with spherical structures secreted by cells that produce them. The diameter of exosomes is much smaller than that of hUC-MSCs, suggesting that exosomes might be a novel and safer therapeutic product of mesenchymal stem cells. As exosomes have been suggested to have biochemical functions similar to those of hUC-MSCs, this study investigated the efficiency of hUC-MSC-derived exosomes in protecting against nonalcoholic steatohepatitis using an MCD-induced mouse model.

methodsHuman umbilical cord mesenchymal stem cell-derived exosomes were extracted and purified. The effect of these exosomes on disease progression in an MCD-induced nonalcoholic steatohepatitis mouse model was investigated.

resultsThe results showed that UC-MSC exosomes intravenously transplanted into mice with MCD-induced NASH improved MCD-induced body weight loss and liver damage in a mouse model. Additionally, the inflammatory cytokines in liver tissue were reduced, which may be caused by exosome-induced macrophage anti-inflammatory phenotypes both in vitro and in vivo. In addition, UC-MSC exosomes reversed PPARα level in ox-LDL-treated hepatocytes in vitro and in NASH mouse liver, which had been downregulated.

conclusionsUC-MSC exosomes alleviate MCD-induced NASH in mice by regulating the anti-inflammatory phenotype of macrophages and by reversing PPARα protein expression in liver cells, which holds great potential in NASH therapy.

Indexed as

ExosomesMesenchymal Stem CellsMesenchymal Stem Cell TransplantationNon-alcoholic Fatty Liver DiseaseAnimalsDisease Models, AnimalHumansMicePPAR alphaUmbilical CordPPAR alphahUC-MSC exosomesMCD mouse modelNonalcoholic steatohepatitisPPARα

Identifiers

PMID36371344
PMCPMC9652856
OpenAlexW4309046002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.