ArticleIndian journal of medical microbiology
Seroepidemiological and genomic investigation of SARS-CoV-2 spread in North East region of India.
Article in Indian journal of medical microbiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 7 citations in OpenAlex.
- BharatSim: An agent-based modelling framework for India.PLoS computational biology · 2024Article
- Leveraging environmental microbial indicators in wastewater for data-driven disease diagnostics.Frontiers in bioengineering and biotechnology · 2024Article
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Authors and funding
19 authors at 2 institutions in 1 country.
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Abstract
purposeSeroepidemiology and genomic surveillance are valuable tools to investigate infection transmission during a pandemic. North East (NE) India is a strategically important region being the gateway connecting the country with Southeast Asia. Here, we examined the spread of SARS-CoV-2 in NE India during the first and second waves of COVID-19 using serological and whole genome sequencing approaches.
methodsqRT-PCR analysis was performed on a selected population (n = 16,295) from June 2020 to July 2021, and metadata was collected. Immunoassays were studied (n = 2026) at three-time points (August 2020, February 2021, and June 2021) and in a cohort (n = 35) for a year. SARS-CoV-2 whole genomes (n = 914) were sequenced and analyzed with those obtained from the databases.
resultsTest positivity rates (TPR) in the first and second waves were 6.34% and 6.64% in Assam, respectively, and a similar pattern was observed in other NE states. Seropositivity in the three time points was 10.63%, 40.3%, and 46.33%, respectively, and neutralizing antibody prevalence was 90.91%, 52.14%, and 69.30%, respectively. Persistence of pan-IgG-N SARS-CoV-2 antibody for over a year was observed among three subjects in the cohort group. Normal variants dominated the first wave, while B.1.617.2 and AY-sublineages dominated the second wave in the region. The prevalence of the variants co-related well with high TPR and seropositivity rate in the region and identified mostly among vaccinated individuals.
conclusionThe COVID-19 first wave in the region witnessed low transmission with the evolution of diverse variants. Seropositivity increased during the study period with over half of the individuals carrying neutralizing antibodies against SARS-CoV-2. High infection and seroprevalence in NE India during the second wave were associated with the dominant emergence of variants of concern.
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