ArticleCardiovascular diabetology2022
The association between fibrinogen-to-albumin ratio (FAR) and adverse prognosis in patients with acute decompensated heart failure at different glucose metabolic states.
Article in Cardiovascular diabetology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 29 citations in OpenAlex.
- Fibrinogen-to-albumin ratio and risk of thrombotic diseases incidence.Thrombosis journal · 2026Article
- Article
- Prognostic value of the C-reactive protein-to-albumin ratio in acute decompensated heart failure across different glucose metabolism statuses.Scientific reports · 2025Article
- Development and validation of a serum inflammatory biomarker-driven machine-learning model for prognostic stratification in surgical limited-stage small cell lung cancer.Translational lung cancer research · 2025Article
- Advancing ICU mortality prediction in community-acquired pneumonia: Combining fibrinogen-to-albumin ratio, CT severity score, PSI, and CURB-65.Biomolecules & biomedicine · 2025Article
- Comparative Analysis of Systemic Inflammatory Biomarkers Across Multiple Antiseizure Medications: A Single-Center Retrospective Cohort Study of 1782 Patients.Journal of clinical medicine · 2025Article
- Relationship Between Morning Blood Pressure Surges and Peripheral Inflammatory Biomarkers in Parkinson's Disease.Biomedicines · 2025Article
- Hypoalbuminaemia and heart failure: A practical review of current evidence.European journal of heart failure · 2025Review
- Association between elevated glycosylated hemoglobin levels and hypertension among US adults: NHANES 2011-2018.BMC cardiovascular disorders · 2025Article
- Fibrinogen-to-albumin ratio predicts mortality in patients with diabetes mellitus and atherosclerotic cardiovascular disease.Frontiers in endocrinology · 2025Article
- Nonlinear relationship between fibrinogen-to-albumin ratio and mortality in critically ill patients with sepsis: a retrospective cohort study.Frontiers in nutrition · 2025Article
- The Relationship Between the Fibrinogen-to-Albumin Ratio and Short-Term Mortality in Chinese Patients With Chronic Heart Failure: A Retrospective Cohort Analysis.Cardiology research and practice · 2025Article
- Prognostic Value of Systemic Inflammation Scores in Patients with Acute Coronary Syndrome Who Underwent Percutaneous Coronary Intervention: A Prospective Cohort Study.Journal of inflammation research · 2025Article
- Prognosis Prediction of Cardiovascular Event With Glucose-Albumin Ratio on Patients With Cancer and Prescribed With Anthracycline.Cancer medicine · 2024Article
- Article
- Association between RDW-SD and prognosis across glycemic status in patients with dilated cardiomyopathy.BMJ open diabetes research & care · 2024Article
- Association between glycemic variability and short-term mortality in patients with acute kidney injury: a retrospective cohort study of the MIMIC-IV database.Scientific reports · 2024Article
- The association between the fibrinogen-to-albumin ratio and delirium after deep brain stimulation surgery in Parkinson's disease.Frontiers in medicine · 2024Article
- Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients.Open medicine (Warsaw, Poland) · 2024Article
- Fibrinogen-to-Albumin Ratio and Long-Term Mortality in Coronary Artery Disease Patients with Different Glucose Metabolism Status.Reviews in cardiovascular medicine · 2023Article
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10 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCirculating fibrinogen-to-albumin ratio (FAR) has been proposed as a novel inflammatory biomarker and a cardiovascular disease risk predictor. However, its prognostic value in patients with acute decompensated heart failure (ADHF) and different glycemic metabolic states remains ambiguous.
methodsA total of 1031 hospitalized patients with ADHF from January 2018 to May 2021 were included in the study. The primary endpoints were the major adverse cardiac and cerebral events (MACCEs). Patients were categorized into high-level FAR (FAR-H) and low-level FAR (FAR-L) groups based on the optimal cut-off value of FAR obtained from restricted cubic spline function analysis. The Kaplan-Meier plots and three multivariate-adjusted Cox proportional hazard models were used to determine the association between FAR and the risk of developing MACCEs in patients with ADHF at different glycemic metabolic states.
resultsMACCEs occurred in 483 (46.8%) patients during a median follow-up time of 520 days. The optimal FAR cut-off value was 0.079. Upon analyzing the Kaplan-Meier plots, the incidence of MACCEs was significantly different between the FAR groups in all patients and patients with diabetes mellitus (p < 0.05). After adjusting for the confounding factors, the hazard ratio (HR) for MACCEs in the FAR-H group was 1.29 compared with the FAR-L group in all patients (Model 3: 95% CI 1.07-1.56, p = 0.007). Additionally, high FAR was associated with MACCEs in three multivariate Cox models (Model 1, HR = 1.52, 95% CI 1.17-1.96, p = 0.002; Model 2, HR = 1.46, 95% CI 1.13-1.89, p = 0.004; Model 3, HR = 1.48, 95% CI 1.14-1.92, p = 0.003) in DM patients. But no significant differences were found between the FAR groups for prediabetes mellitus (Pre-DM) and normal glucose regulation (NGR) using the three Cox models (all p-values were > 0.05).
conclusionsElevated FAR was independently associated with poor prognosis in patients with ADHF and DM and thus could be used as a risk stratification tool and a potential therapeutic target in the future.
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