Evidence map›Paper›PMID 36370956›Full record

ArticleNeuroImage2022

Older adults with perivascular spaces exhibit cerebrovascular reactivity deficits.

Arunima Kapoor, Belinda Yew, Jung Yun Jang, Shubir Dutt, Yanrong Li, John Paul M Alitin, Aimee Gaubert, Jean K Ho, Anna E Blanken, Isabel J Sible and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Arunima KapoorDepartment of Psychological Science, University of California, Irvine, CA, USA.
Belinda YewDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Jung Yun JangInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Shubir DuttDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Yanrong LiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
John Paul M AlitinInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Aimee GaubertInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Jean K HoInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Anna E BlankenSan Francisco Veterans Affairs Health Care System & Department of Psychiatry, University of California, San Francisco, CA, USA.
Isabel J SibleDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Anisa MarshallDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Xingfeng ShaoStevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.
Mara MatherDavis School of Gerontology and Department of Psychology, University of Southern California, Los Angeles, CA, USA.
Danny J J WangStevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.
Daniel A NationDepartment of Psychological Science, University of California, Irvine, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA. Electronic address: dnation@uci.edu.
University of California, Irvine · USUniversity of Southern California · USUniversity of California, San Francisco · US

Funding

UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
NIA NIH HHS P01 AG052350NIA NIH HHS P50 AG016573NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228
6 · The paper itself

Abstract

backgroundPerivascular spaces on brain magnetic resonance imaging (MRI) may indicate poor fluid drainage in the brain and have been associated with numerous neurological conditions. Cerebrovascular reactivity (CVR) is a marker of cerebrovascular function and represents the ability of cerebral blood vessels to regulate cerebral blood flow in response to vasodilatory or vasoconstrictive stimuli. We aimed to examine whether pathological widening of the perivascular space in older adults may be associated with deficits in CVR.

methodsIndependently living older adults free of dementia or clinical stroke were recruited from the community and underwent brain MRI. Pseudo-continuous arterial spin labeling MRI quantified whole brain cerebral perfusion at rest and during CVR to hypercapnia and hypocapnia induced by visually guided breathing exercises. Perivascular spaces were visually scored using existing scales.

resultsThirty-seven independently living older adults (mean age = 66.3 years; SD = 6.8; age range 55-84 years; 29.7% male) were included in the current analysis. Multiple linear regression analysis revealed a significant negative association between burden of perivascular spaces and global CVR to hypercapnia (B = -2.0, 95% CI (-3.6, -0.4), p = .015), adjusting for age and sex. Perivascular spaces were not related to CVR to hypocapnia. DISCUSSION: Perivascular spaces are associated with deficits in cerebrovascular vasodilatory response, but not vasoconstrictive response. Enlargement of perivascular spaces could contribute to, or be influenced by, deficits in CVR. Additional longitudinal studies are warranted to improve our understanding of the relationship between cerebrovascular function and perivascular space enlargement.

Indexed as

Cerebrovascular CirculationHypercapniaAgedAged, 80 and overBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedVasodilationCerebrovascular reactivityPerivascular spacesSmall vessel disease

Identifiers

PMID36370956
PMCPMC10033456
OpenAlexW4308620305

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.