Evidence map›Paper›PMID 36370877›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2022

Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis.

Emilie Audouard, Fanny Michel, Vanessa Pierroz, Taeuk Kim, Lisa Rousselot, Béatrix Gillet-Legrand, Gaëlle Dufayet-Chauffaut, Peter Buchmann, Michael Florea, Alexander Khel and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Optogenetics in oral and craniofacial research.Journal of Zhejiang University. Science. B · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 4 countries.

Emilie AudouardNeuroGenCell, Paris Brain Institute - ICM, INSERM, CNRS, AP-HP, Sorbonne Université; Hôpital de la Pitié Salpêtrière, Paris, France.
Fanny MichelDepartment of Biosystems Science and Engineering, D-BSSE, ETH Zürich, Basel, Switzerland.
Vanessa PierrozDepartment of Biosystems Science and Engineering, D-BSSE, ETH Zürich, Basel, Switzerland.
Taeuk KimDepartment of Biosystems Science and Engineering, D-BSSE, ETH Zürich, Basel, Switzerland.
Lisa RousselotNeuroGenCell, Paris Brain Institute - ICM, INSERM, CNRS, AP-HP, Sorbonne Université; Hôpital de la Pitié Salpêtrière, Paris, France.
Béatrix Gillet-LegrandNeuroGenCell, Paris Brain Institute - ICM, INSERM, CNRS, AP-HP, Sorbonne Université; Hôpital de la Pitié Salpêtrière, Paris, France.
Gaëlle Dufayet-ChauffautNeuroGenCell, Paris Brain Institute - ICM, INSERM, CNRS, AP-HP, Sorbonne Université; Hôpital de la Pitié Salpêtrière, Paris, France.
Peter BuchmannDepartment of Biosystems Science and Engineering, D-BSSE, ETH Zürich, Basel, Switzerland.
Michael FloreaDepartment of Biosystems Science and Engineering, D-BSSE, ETH Zürich, Basel, Switzerland.
Alexander KhelGeneXplain GmbH, Wolfenbuettel, Germany.
Kamilya AltynbekovaGeneXplain GmbH, Wolfenbuettel, Germany.
Claudia DelgaldoEurecat, Centre Tecnològic de Catalunya, Functional Printing and Embedded Devices Unit, Mataró, Spain.
Encarna EscuderoEurecat, Centre Tecnològic de Catalunya, Functional Printing and Embedded Devices Unit, Mataró, Spain.
Alejandra Ben Aissa SolerEurecat, Centre Tecnològic de Catalunya, Functional Printing and Embedded Devices Unit, Mataró, Spain.
Nathalie CartierNeuroGenCell, Paris Brain Institute - ICM, INSERM, CNRS, AP-HP, Sorbonne Université; Hôpital de la Pitié Salpêtrière, Paris, France.
Francoise PiguetNeuroGenCell, Paris Brain Institute - ICM, INSERM, CNRS, AP-HP, Sorbonne Université; Hôpital de la Pitié Salpêtrière, Paris, France.
Marc FolcherDepartment of Biosystems Science and Engineering, D-BSSE, ETH Zürich, Basel, Switzerland; Institute of Molecular and Clinical Ophthalmology, IOB, Basel, Switzerland. Electronic address: Marc.folcher@iob.ch.
ETH Zurich · CHCentre Tecnologic de Telecomunicacions de Catalunya · ESInstitut du Cerveau · FRGeneXplain (Germany) · DEAssistance Publique – Hôpitaux de Paris · FRInserm · FRInstitute of Molecular and Clinical Ophthalmology Basel · CHPitié-Salpêtrière Hospital · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wireless powered optogenetic cell-based implant provides a strategy to deliver subcutaneously therapeutic proteins. Immortalize Human Mesenchymal Stem Cells (hMSC-TERT) expressing the bacteriophytochrome diguanylate cyclase (DGCL) were validated for optogenetic controlled interferon-β delivery (Optoferon cells) in a bioelectronic cell-based implant. Optoferon cells transcriptomic profiling was used to elaborate an in-silico model of the recombinant interferon-β production. Wireless optoelectronic device integration was developed using additive manufacturing and injection molding. Implant cell-based optoelectronic interface manufacturing was established to integrate industrial flexible compact low-resistance screen-printed Near Field Communication (NFC) coil antenna. Optogenetic cell-based implant biocompatibility, and device performances were evaluated in the Experimental Autoimmune Encephalomyelitis (EAE) mouse model of multiple sclerosis.

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisAnimalsDisease Models, AnimalGene ExpressionHumansInterferon-betaMiceMice, Inbred C57BLInterferon-betaBioelectronicCell-based deviceDrug deliveryInterferonMultiple sclerosisOptogenetic

Identifiers

PMID36370877
PMCPMC9733677
OpenAlexW4308890857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.