Evidence map›Paper›PMID 36370807›Full record

ArticleJournal of lipid research2022

Biosynthesis of prostaglandin 15dPGJ

Julia Steinmetz-Späh, Jianyang Liu, Rajkumar Singh, Maria Ekoff, Sanjaykumar Boddul, Xiao Tang, Filip Bergqvist, Helena Idborg, Pascal Heitel, Elin Rönnberg and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. DecipheringmSystems · 2024
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Julia Steinmetz-SpähDivision of Rheumatology, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Jianyang LiuDivision of Rheumatology, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Rajkumar SinghDivision of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Maria EkoffDivision of Immunology and Allergy, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Sanjaykumar BoddulDivision of Rheumatology, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Xiao TangDivision of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Filip BergqvistDivision of Rheumatology, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Helena IdborgDivision of Rheumatology, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Pascal HeitelInstitute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Frankfurt, Germany.
Elin RönnbergDivision of Immunology and Allergy, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Daniel MerkInstitute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Frankfurt, Germany.
Fredrik WermelingDivision of Rheumatology, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Jesper Z HaeggströmDivision of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Gunnar NilssonDivision of Immunology and Allergy, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Dieter SteinhilberInstitute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Frankfurt, Germany.
Karin LarssonDivision of Rheumatology, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Marina KorotkovaDivision of Rheumatology, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Per-Johan JakobssonDivision of Rheumatology, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. Electronic address: per-johan.jakobsson@ki.se.
Karolinska University Hospital · SEGoethe University Frankfurt · DEKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibition of microsomal prostaglandin E synthase-1 (mPGES-1) results in decreased production of proinflammatory PGE

Indexed as

CysteineProstaglandinsAnimalsCyclooxygenase 2GlutathioneGlutathione TransferaseHumansLipopolysaccharidesMacrophagesMast CellsMiceProstaglandin D2Prostaglandin-E SynthasesCyclooxygenase 2CysteineGlutathioneGlutathione TransferaseLipopolysaccharidesProstaglandin D2Prostaglandin-E SynthasesProstaglandinscyclopentenonesGSHimmune cellsinflammationlipid metabolismMichael adductsmicrosomal glutathione S-transferase-3mPGES-1 inhibitionPGD(2)/15-deoxy-Δ(12,14)-prostaglandin J(2)resolution

Identifiers

PMID36370807
PMCPMC9792570
OpenAlexW4308741332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.