ArticleThe Journal of physiology2023
Muscle glycogen unavailability and fat oxidation rate during exercise: Insights from McArdle disease.
Article in The Journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Divergent Changes in Peak Fat Oxidation and FatScandinavian journal of medicine & science in sports · 2025Trial
- Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability: Insights from McArdle disease.Journal of sport and health science · 2024Trial
- Skeletal muscle proteomics links mitochondrial abundance with peak fat oxidation in physically active young males.The Journal of physiology · 2026Article
- An exercise intervention in children and young adults with McArdle disease: feasibility, acceptability, and clinical outcomes.Orphanet journal of rare diseases · 2026Article
- Energy metabolism in different skeletal muscles and muscle fibers: implications for injury and dietary supplementation.Pflugers Archiv : European journal of physiology · 2025Review
- Aerobic capacity and muscle proteome: Insights from a mouse model.Experimental physiology · 2025Article
- Effects of endurance training under calorie restriction on energy substrate metabolism in mouse skeletal muscle and liver.The journal of physiological sciences : JPS · 2024Article
- Dietary Polysaccharides Exert Anti-Fatigue Functions via the Gut-Muscle Axis: Advances and Prospectives.Foods (Basel, Switzerland) · 2023Review
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbohydrate availability affects fat metabolism during exercise; however, the effects of complete muscle glycogen unavailability on maximal fat oxidation (MFO) rate remain unknown. Our purpose was to examine the MFO rate in patients with McArdle disease, comprising an inherited condition caused by complete blockade of muscle glycogen metabolism, compared to healthy controls. Nine patients (three women, aged 36 ± 12 years) and 12 healthy controls (four women, aged 40 ± 13 years) were studied. Several molecular markers of lipid transport/metabolism were also determined in skeletal muscle (gastrocnemius) and white adipose tissue of McArdle (Pygm p.50R*/p.50R*) and wild-type male mice. Peak oxygen uptake (
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