Evidence map›Paper›PMID 36370322›Full record

ReviewOdontology2023

Toxicity of resin-matrix cements in contact with fibroblast or mesenchymal cells.

Marta Martinez-Gonzalez, Rita C Fidalgo-Pereira, Orlanda Torres, Filipe Silva, Bruno Henriques, Mutlu Özcan, Júlio C M Souza

Abstract readReview
PubMed Publisher
In one paragraph

Review in Odontology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marta Martinez-GonzalezUniversity Institute of Health Sciences (IUCS), CESPU, 4585-116, Gandra PRD, Portugal.
Rita C Fidalgo-PereiraUniversity Institute of Health Sciences (IUCS), CESPU, 4585-116, Gandra PRD, Portugal.
Orlanda TorresUniversity Institute of Health Sciences (IUCS), CESPU, 4585-116, Gandra PRD, Portugal.
Filipe SilvaCenter for Micro Electro Mechanical Systems (CMEMS-UMINHO), University of Minho, Campus Azurém, 4800-058, Guimarães, Portugal.
Bruno HenriquesCenter for Micro Electro Mechanical Systems (CMEMS-UMINHO), University of Minho, Campus Azurém, 4800-058, Guimarães, Portugal.
Mutlu ÖzcanDivision of Dental Biomaterials, Clinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich, 8032, Zurich, Switzerland.
Júlio C M SouzaUniversity Institute of Health Sciences (IUCS), CESPU, 4585-116, Gandra PRD, Portugal. jsouza@dem.uminho.pt.ORCID http://orcid.org/0000-0001-7999-4009

Funding

Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa POCI-01-0145-FEDER-031035
6 · The paper itself

Abstract

The main aim of this study was to perform an integrative review on the toxic effects of resin-matrix cements and their products in contact with fibroblasts or mesenchymal cells. A bibliographic search was performed on PubMed using the following search terms: "cytotoxicity" AND "fibroblast" OR "epithelial" OR "mesenchymal" AND "polymerization" OR "degree of conversion" OR "methacrylate" OR "monomer" AND "resin cement" OR "resin-based cement". The initial search in the available database yielded a total of 277 articles of which 21 articles were included in this review. A decrease in the viability of mouse fibroblasts ranged between 13 and 15% that was recorded for different resin-matrix cements after light curing exposure for 20 s. The viability of human fibroblasts was recorded at 83.11% after light curing for 20 s that increased up to 90.9% after light curing exposure for 40 s. Most of the studies linked the highest toxicity levels when the cells were in contact with Bis-GMA followed by UDMA, TEGDMA and HEMA. Resin-matrix cements cause a cytotoxic reaction when in contact with fibroblasts or mesenchymal cells due to the release of monomers from the polymeric matrix. The amount of monomers released from the resin matrix and their cytotoxicity depends on the polymerization parameters.

Indexed as

Polymethacrylic AcidsResin CementsAnimalsBisphenol A-Glycidyl MethacrylateFibroblastsHumansMaterials TestingMethacrylatesMicePolymerizationBisphenol A-Glycidyl MethacrylateMethacrylatesPolymethacrylic AcidsResin CementsCytotoxicityDegree of conversionFibroblastPolymerizationResin cement

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.