Evidence map›Paper›PMID 36370259›Full record

ArticleApoptosis : an international journal on programmed cell death2023

Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury.

Dongju Zhu, Jie Zhong, Xuefeng Gong, Xiang Wu

Abstract read
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In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Loganin Alleviates CClChinese journal of integrative medicine · 2026
    Article
  4. Review
  5. Article
  6. Mitophagy in kidney transplantation ischemia-reperfusion injury.International urology and nephrology · 2026
    Review
  7. Review
  8. Review
  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dongju ZhuDepartment of Nephrology, Affiliated Hospital of Panzhihua University, Panzhihua, Sichuan, China.
Jie ZhongDepartment of Nephrology, Affiliated Hospital of Panzhihua University, Panzhihua, Sichuan, China.
Xuefeng GongDepartment of Nephrology, Affiliated Hospital of Panzhihua University, Panzhihua, Sichuan, China.
Xiang WuDepartment of Pediatrics, Panzhihua Central Hospital, Panzhihua, China. 515080268@qq.com.
Panzhihua University · CNPanzhihua Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemia-reperfusion (IR) injury is one of the main causes of acute kidney disease (AKI). Several studies have shown that mitochondrial damage, which leads to increased production of reactive oxygen species (ROS), plays a vital role in the pathogenesis of IR-induced AKI. Increased ROS production can cause oxidative damage and activate the inflammasome in renal tubular cells, ultimately resulting in apoptosis or necrosis. Mitophagy is a type of selective autophagy that plays a protective role in AKI by regulating the quality of mitochondria and reducing the production of ROS. We previously reported that the augmenter of liver regeneration (ALR) exhibits antiapoptotic and antioxidant functions, although the precise mechanisms of action need to be studied further. In the current study, ALR was overexpressed and an in vitro model of IR injury was constructed. The overexpression of ALR reduced the production of mitochondria-derived ROS (mtROS), the activation of the NLRP3 inflammasome, and the rate of apoptosis. Moreover, this suppression of mtROS production and inflammasome activation was mediated through the PTEN-induced kinase 1 (PINK1)/Parkin pathway of mitophagy. These results suggest that ALR can alleviate IR-induced apoptosis via the PINK1/Parkin mitophagy pathway to reduce the production of mtROS and limit the activation of the NLRP3 inflammasome.

Indexed as

Acute Kidney InjuryReperfusion InjuryApoptosisHumansInflammasomesIschemiaLiver RegenerationMitochondriaMitophagyNLR Family, Pyrin Domain-Containing 3 ProteinProtein KinasesReactive Oxygen SpeciesReperfusionUbiquitin-Protein LigasesInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinProtein KinasesReactive Oxygen SpeciesUbiquitin-Protein LigasesAcute kidney injuryAugmenter of liver regenerationInflammationIschemia–reperfusionMitophagyReactive oxygen species

Identifiers

PMID36370259
OpenAlexW4308835070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.