Evidence map›Paper›PMID 36370232›Full record

ArticleArchives of microbiology2022

Inhibition of Klebsiella pneumoniae carbapenemases by mycocins produced by Wickerhamomyces anomalus.

Bruna Larissa Nascimento, Eloiza Cristina Martelli, Jessica Cassia da Silva, Mateus Foltz Delabeneta, Lana Rubia Backes Rosseto, Daniele Schaab Boff Junges, Ana Paula Paris, Cristiane Persel, Claudete Rodrigues Paula, Rita de Cássia Garcia Simão and 1 more

Abstract read
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In one paragraph

Article in Archives of microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Antimicrobial activity of immobilized mycocins in sodium alginate on fecal coliforms.Water science and technology : a journal of the International Association on Water Pollution Research · 2025
    Article
  3. Probiotic Yeasts: A Developing Reality?Journal of fungi (Basel, Switzerland) · 2024
    Review
  4. The Life ofMicroorganisms · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bruna Larissa NascimentoUniversity Hospital From Western Paraná State University, At 3224, Tancredo Neves Avenue, Cascavel City, Paraná, 85806-470, Brazil.
Eloiza Cristina MartelliUniversity Hospital From Western Paraná State University, At 3224, Tancredo Neves Avenue, Cascavel City, Paraná, 85806-470, Brazil.
Jessica Cassia da SilvaUniversity Hospital From Western Paraná State University, At 3224, Tancredo Neves Avenue, Cascavel City, Paraná, 85806-470, Brazil.
Mateus Foltz DelabenetaUniversity Hospital From Western Paraná State University, At 3224, Tancredo Neves Avenue, Cascavel City, Paraná, 85806-470, Brazil.
Lana Rubia Backes RossetoUniversity Hospital From Western Paraná State University, At 3224, Tancredo Neves Avenue, Cascavel City, Paraná, 85806-470, Brazil.
Daniele Schaab Boff JungesUniversity Hospital From Western Paraná State University, At 3224, Tancredo Neves Avenue, Cascavel City, Paraná, 85806-470, Brazil.
Ana Paula ParisUniversity Hospital From Western Paraná State University, At 3224, Tancredo Neves Avenue, Cascavel City, Paraná, 85806-470, Brazil.
Cristiane PerselUniversity Hospital From Western Paraná State University, At 3224, Tancredo Neves Avenue, Cascavel City, Paraná, 85806-470, Brazil.
Claudete Rodrigues PaulaFaculty of Dentistry, Department of Stomatology, University of São Paulo, São Paulo, São Paulo, Brazil.
Rita de Cássia Garcia SimãoUniversity Hospital From Western Paraná State University, At 3224, Tancredo Neves Avenue, Cascavel City, Paraná, 85806-470, Brazil.
Rinaldo Ferreira GandraUniversity Hospital From Western Paraná State University, At 3224, Tancredo Neves Avenue, Cascavel City, Paraná, 85806-470, Brazil. rinaldo.gandra@unioeste.br.ORCID http://orcid.org/0000-0003-3985-9392

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New alternatives have been under study as treatment due to the problem of multidrug-resistant bacteria. Among them, Wickerhamomyces anomalus mycocins have shown a great potential against several microorganisms since they have high antimicrobial activity, as well as they can be used as fast available nutrients and stand several extreme conditions. In this way, Klebsiella pneumoniae carbapenemases inhibition by mycocins produced by W. anomalus is important. Microdilution assays were carried out to evaluate strains inhibition in liquid medium and the test in solid medium were carried out. Toxicity was evaluated by both hemolysis and Artemia salina Leach tests. W. anomalus supernatant showed 2.36 U/mg β-glucanases activity, and antimicrobial activity was evidenced in 100% Klebsiella pneumoniae carbapenemase strains up to 0.12 U/mg concentration. Besides, there was low toxicity in hemolysis and Artemia salina Leach tests. It is suggested that W. anomalus mycocins may be an alternative to develop new antimicrobial substances.

Indexed as

Anti-Infective AgentsKlebsiella pneumoniaeAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesHemolysisMicrobial Sensitivity TestsSaccharomycetalesAnti-Bacterial AgentsAnti-Infective AgentsBacterial Proteinsbeta-LactamasescarbapenemaseAntimicrobial activityBacterial resistanceKiller toxinKPC

Identifiers

PMID36370232

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.