Evidence map›Paper›PMID 36370129›Full record

ReviewPain practice : the official journal of World Institute of Pain2023

The applications of cryoneurolysis for acute and chronic pain management.

Emily Biel, Edwin N Aroke, John Maye, Sarah Jingying Zhang

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pain practice : the official journal of World Institute of Pain, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07303582 (Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07303582 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities (ICE): a Pilot Randomised Controlled Trial

TypeinterventionalSponsorOxford University Hospitals NHS TrustRan2025 to 2026Enrolled50ConditionsCentreal Neurological Condition, Acquired Brain Injury (Including Stroke), Multiple Sclerosis, Spinal Cord InjuryArmsCryoneurolysis, Botulinum toxin
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Cryoneurolysis of Sacral Lateral Branches for Chronic Sacroiliac Joint Pain: A Multicenter Retrospective Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
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  7. Review
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  12. Review
  13. Cryoneurolysis for the management of pain secondary to obstetrical brachial plexus injury: a case report.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emily BielNurse Anesthesiology Program, University of South Florida, Tampa, Florida, USA.
Edwin N ArokeUniversity of Alabama at Birmingham School of Nursing, Birmingham, Alabama, USA.ORCID 0000-0002-8355-0870
John MayeSchool of Nursing, University of South Florida, Tampa, Florida, USA.
Sarah Jingying ZhangSchool of Nursing, University of South Florida, Tampa, Florida, USA.ORCID 0000-0003-4638-0611

Funding

Epigenomic and Gene Expression Signatures of Racial Differences in Chronic Low Back PainR01AR079178 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AROKE, EDWIN NGOMUEH · 2021 to 2024
$1.6M
NIAMS NIH HHS R01 AR079178
6 · The paper itself

Abstract

backgroundCryoneurolysis is a term used to describe the application of extreme cold to targeted nerve tissue. The primary goal of the application of a thermal neurolytic technique is to disrupt the conduction of pain signals from the periphery to the central nervous system and eliminate or diminish the experience of pain. Recent advancements in ultrasound technology coupled with the development and approval of handheld devices specifically designed to deliver cryoneurolysis has expanded the use of this modality in the perioperative setting. APPLICATION: Surgical procedures including total knee arthroplasties, shoulder arthroplasties, thoracotomies, and mastectomies have all demonstrated long-term pain relief benefits when cryoneurolysis has been administered days to weeks prior to the planned procedure. In addition, the newly designed handheld device allows for office-based clinical use and has been utilized for various chronic pain conditions including neuropathic and phantom limb pain.

conclusionThe evidence clearly demonstrates that cryoneurolysis has a low risk profile and when administered appropriately, provides prolonged analgesia without promoting motor blockade. This narrative review article describes the unique mechanism of action of cryoneurolysis for prolonged pain relief and provides emerging evidence to support its applications in both acute and chronic pain management.

Indexed as

Arthroplasty, Replacement, KneeNerve BlockPeripheral Nervous System DiseasesPhantom LimbHumansPain Managementacute and chronic pain managementcryoanalgesiacryoneurolysisregional anesthesiaultrasound

Identifiers

PMID36370129
PMCPMC10107282

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.