Evidence map›Paper›PMID 36370099›Full record

ArticleNucleic acids research2023

The ProteomeXchange consortium at 10 years: 2023 update.

Eric W Deutsch, Nuno Bandeira, Yasset Perez-Riverol, Vagisha Sharma, Jeremy J Carver, Luis Mendoza, Deepti J Kundu, Shengbo Wang, Chakradhar Bandla, Selvakumar Kamatchinathan and 12 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 512 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
512citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

512 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Bacterial stress responses lower mRNA-protein level correlations.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  6. Review
  7. Unraveling the Glycosylation Machinery ofInternational journal of molecular sciences · 2026
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  13. Skewed MHC Class I Peptide Presentation in Psoriatic Arthritis.International journal of molecular sciences · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

452 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Eric W DeutschInstitute for Systems Biology, Seattle WA 98109, USA.
Nuno BandeiraCenter for Computational Mass Spectrometry, University of California, San Diego (UCSD), La Jolla, CA 92093, USA.
Yasset Perez-RiverolEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.ORCID 0000-0001-6579-6941
Vagisha SharmaUniversity of Washington, Seattle, WA 98195, USA.
Jeremy J CarverCenter for Computational Mass Spectrometry, University of California, San Diego (UCSD), La Jolla, CA 92093, USA.
Luis MendozaInstitute for Systems Biology, Seattle WA 98109, USA.
Deepti J KunduEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Shengbo WangEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Chakradhar BandlaEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Selvakumar KamatchinathanEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Suresh HewapathiranaEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Benjamin S PullmanCenter for Computational Mass Spectrometry, University of California, San Diego (UCSD), La Jolla, CA 92093, USA.
Julie WertzCenter for Computational Mass Spectrometry, University of California, San Diego (UCSD), La Jolla, CA 92093, USA.
Zhi SunInstitute for Systems Biology, Seattle WA 98109, USA.
Shin KawanoFaculty of Contemporary Society, Toyama University of International Studies, Toyama 930-1292, Japan.
Shujiro OkudaNiigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.ORCID 0000-0002-7704-8104
Yu WatanabeNiigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Brendan MacLeanUniversity of Washington, Seattle, WA 98195, USA.
Michael J MacCossUniversity of Washington, Seattle, WA 98195, USA.
Yunping ZhuBeijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing 102206, China.ORCID 0000-0002-7320-7411
Yasushi IshihamaGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Juan Antonio VizcaínoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.ORCID 0000-0002-3905-4335

Funding

Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI Thomas Girke, NICHOLAS Joseph SCHORK · 2004 to 2026
$102.6M
Project 4: Novel reagent development to enable molecular characterizationU19AG065156 · NIA · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL · 2020 to 2024
$15.9M
Seattle Quant: A Resource for the Skyline Software EcosystemR24GM141156 · NIGMS · UNIVERSITY OF WASHINGTON · PI Michael MacCoss · 2021 to 2026
$6.7M
Shortening the development cycle time of Trans Proteomic Pipeline tools with high performance computingR01GM087221 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI DEUTSCH, ERIC, MORITZ, ROBERT L · 2010 to 2021
$6.0M
Quantifying proteins in plasma to democratize personalized medicine for patients with type 1 diabetesU01DK121289 · NIDDK · UNIVERSITY OF WASHINGTON · PI HOOFNAGLE, ANDREW N · 2019 to 2021
$1.9M
MassIVE.quant: a curated and scalable community resource for quantitative proteomicsR01LM013115 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANDEIRA, NUNO · 2019 to 2022
$1.3M
Advancing data and metadata standards for proteomics mass spectraR24GM127667 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI DEUTSCH, ERIC · 2017 to 2019
$1.2M
NIA NIH HHS U19 AG023122NIA NIH HHS U19 AG065156NIDDK NIH HHS U01 DK121289NIGMS NIH HHS R01 GM087221NIGMS NIH HHS R24 GM127667NIGMS NIH HHS R24 GM141156NLM NIH HHS R01 LM013115Wellcome Trust
6 · The paper itself

Abstract

Mass spectrometry (MS) is by far the most used experimental approach in high-throughput proteomics. The ProteomeXchange (PX) consortium of proteomics resources (http://www.proteomexchange.org) was originally set up to standardize data submission and dissemination of public MS proteomics data. It is now 10 years since the initial data workflow was implemented. In this manuscript, we describe the main developments in PX since the previous update manuscript in Nucleic Acids Research was published in 2020. The six members of the Consortium are PRIDE, PeptideAtlas (including PASSEL), MassIVE, jPOST, iProX and Panorama Public. We report the current data submission statistics, showcasing that the number of datasets submitted to PX resources has continued to increase every year. As of June 2022, more than 34 233 datasets had been submitted to PX resources, and from those, 20 062 (58.6%) just in the last three years. We also report the development of the Universal Spectrum Identifiers and the improvements in capturing the experimental metadata annotations. In parallel, we highlight that data re-use activities of public datasets continue to increase, enabling connections between PX resources and other popular bioinformatics resources, novel research and also new data resources. Finally, we summarise the current state-of-the-art in data management practices for sensitive human (clinical) proteomics data.

Indexed as

ProteomicsSoftwareComputational BiologyDatabases, ProteinHumansMass Spectrometry

Identifiers

PMID36370099
PMCPMC9825490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.