Evidence map›Paper›PMID 36369906›Full record

ReviewCancer reports (Hoboken, N.J.)2023

Clinical characteristics, prognostic factors, and long-term outcomes associated with epithelial malignancies of the thymus: A 20-year single-institution experience.

Ellery Altshuler, Akash Mathavan, Akshay Mathavan, Urszula Krekora, Mohit Mathavan, Keegan Hones, Karen Daily

Open access · goldFull text readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer reports (Hoboken, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Machine Learning Models Derived from [Bioengineering (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ellery AltshulerDepartment of Internal Medicine, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-1811-317X
Akash MathavanCollege of Medicine, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-3496-2542
Akshay MathavanCollege of Medicine, University of Florida, Gainesville, Florida, USA.
Urszula KrekoraCollege of Medicine, University of Central Florida, Orlando, Florida, USA.
Mohit MathavanDepartment of Internal Medicine, St George's University School of Medicine, Great River, New York, USA.
Keegan HonesCollege of Medicine, University of Florida, Gainesville, Florida, USA.
Karen DailyDepartment of Internal Medicine, University of Florida, Gainesville, Florida, USA.
University of Florida · USSt. George's School · USUniversity of Central Florida · USUniversity of Florida Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThymic epithelial tumors are rare and include thymomas and thymic carcinomas. There is scarce literature characterizing prognostic factors and long-term outcomes in these tumors.

aimsThis review aims to describe disease features of thymomas and thymic carcinomas and to report clinical differences among thymoma histological subtypes. METHODS AND

resultsA retrospective chart review was performed at the University of Florida Shands Hospital, a tertiary care academic medical center in Gainesville, Florida, USA. The review included clinical data of adults with thymic epithelial tumors diagnosed between 2001 and 2021. Significant associations among demographics, histology, stage, and outcomes were investigated. Thymoma subgroup analysis was performed using histological subtype and sex. Forty patients with thymoma and seven patients with thymic carcinoma were included in the final analysis. Among those with thymomas, patients with subtype B1, B2, or B3 tumors were younger, had larger tumors, and presented with higher stage disease when compared to those with subtypes A or AB. Tumor recurrence was most common in subtype B2 and B3 tumors (50.0% and 16.7% vs. 0%; p < .01). However, there was no significant difference in overall survival between histologic subtypes. Compared to females, males with thymomas had superior overall survival (103.0 vs. 62.9 months; p = .021) despite presenting with larger tumors (9.8 vs. 5.8 cm; p = .041). Concomitant myasthenia gravis was associated with increased recurrence but not worsened mortality. Compared to thymomas, patients with thymic carcinoma presented with higher-stage disease and had poorer 5-year survival (50.0% vs. 93.1%; p < .01).

conclusionThis study affirmed pathologic stage and resectability as prognostic factors for thymic epithelial tumors. New findings include inferior overall survival in female patients and higher recurrence rates in those with thymomas and concomitant myasthenia gravis.

Indexed as

Myasthenia GravisNeoplasms, Glandular and EpithelialThymomaThymus NeoplasmsAdultFemaleHumansMaleNeoplasm Recurrence, LocalPrognosisRetrospective Studiesthymic carcinomathymic epithelial tumorsthymoma

Identifiers

PMID36369906
PMCPMC10026295
OpenAlexW4308834347

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read245
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.