ArticleBiophysical journal2023
Aggregation controlled by condensate rheology.
Article in Biophysical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Protein codes and mobility together shape cellular function and disease.Trends in biochemical sciences · 2026Review
- Delay-facilitated self-assembly in compartmentalized systems.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Computer Simulations Show That Liquid-Liquid Phase Separation Enhances Self-Assembly.ACS nano · 2025Article
- The mechanobiology of biomolecular condensates.Biophysics reviews · 2025Review
- Phage probes couple to DNA relaxation dynamics to reveal universal behavior across scales and regimes.Soft matter · 2025Article
- The role of biomolecular condensates in protein aggregation.Nature reviews. Chemistry · 2024Review
- Physical limits to acceleration of enzymatic reactions inside phase-separated compartments.Physical review. E · 2024Article
- Self-assembly coupled to liquid-liquid phase separation.PLoS computational biology · 2023Article
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Authors and funding
3 authors.
Funding
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Abstract
Biomolecular condensates in living cells can exhibit a complex rheology, including viscoelastic and glassy behavior. This rheological behavior of condensates was suggested to regulate polymerization of cytoskeletal filaments and aggregation of amyloid fibrils. Here, we theoretically investigate how the rheological properties of condensates can control the formation of linear aggregates. To this end, we propose a kinetic theory for linear aggregation in coexisting phases, which accounts for the aggregate size distribution and the exchange of aggregates between inside and outside of condensates. The rheology of condensates is accounted in our model via aggregate mobilities that depend on aggregate size. We show that condensate rheology determines whether aggregates of all sizes or dominantly small aggregates are exchanged between condensate inside and outside on the timescale of aggregation. As a result, the ratio of aggregate numbers inside to outside of condensates differs significantly. Strikingly, we also find that weak variations in the rheological properties of condensates can lead to a switch-like change of the number of aggregates. These results suggest a possible physical mechanism for how living cells could control linear aggregation in a switch-like fashion through variations in condensate rheology.
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