ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023
Considerations on gradual glutamate accumulation related to cognitive task performance.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Maternal sleep deprivation disrupts glutamate metabolism in offspring rats.Zoological research · 2024Article
- Self-perceptual blindness to mental fatigue in mining workers.Frontiers in neuroergonomics · 2024Article
- Estimating the synaptic density deficit in Alzheimer's disease using multi-contrast CEST imaging.PloS one · 2024Article
- Peripheral inflammation and neurocognitive impairment: correlations, underlying mechanisms, and therapeutic implications.Frontiers in aging neuroscience · 2023Review
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Abstract
Long-lasting activities with high demand in cognitive control are known to result in cognitive fatigue. However, the reason for control cost inflation remains elusive. A neurometabolic account was proposed in a recent study combining magnetic resonance spectroscopy (MRS) with daylong execution of behavioral tasks. It suggests that control cost during high-demand work is related to the necessity of recycling potentially toxic substances, specifically glutamate, which may accumulate extracellularly. As MRS provides estimates of metabolite concentrations, further evaluations are possible how well this hypothesis fits with fundamental consequences from the dynamic equilibrium of intercompartmental glutamate distributions.
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