ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2023
The basolateral amygdala to lateral septum circuit is critical for regulating social novelty in mice.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 27 citations in OpenAlex.
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- Article
- Role of molecularly defined lateral septum cell types and circuits in social behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Parallel neuronal structural plasticity with memory trace formation in the orbitofrontal cortex.Nature communications · 2025Article
- Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal.Neuron · 2025Article
- The Amygdala Regulates Social Motivation for Selective Vocal Imitation in Zebra Finches.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Social dominance in rats is a determinant of susceptibility to stress.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Auditory fear memory retrieval requires BLA-LS and LS-VMH circuitries via GABAergic and dopaminergic neurons.EMBO reports · 2025Article
- Somatostatin-expressing interneurons of prefrontal cortex modulate social deficits in the Magel2 mouse model of autism.Molecular autism · 2025Article
- Input-specific properties of excitatory synapses on oxytocin receptor-expressing neurons in the lateral septum.Journal of neurophysiology · 2024Article
- Cingulate to septal circuitry facilitates the preference to affiliate with large peer groups.Current biology : CB · 2024Article
- A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice.Disease models & mechanisms · 2024Article
- TrkB-dependent regulation of molecular signaling across septal cell types.Translational psychiatry · 2024Article
- Developmental origin and local signals cooperate to determine septal astrocyte identity.bioRxiv : the preprint server for biology · 2023Article
- A developmentally defined population of neurons in the lateral septum controls responses to aversive stimuli.bioRxiv : the preprint server for biology · 2023Article
- Biased brain and behavioral responses towards kin in males of a communally breeding species.Scientific reports · 2023Article
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10 authors at 2 institutions in 1 country.
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Abstract
The lateral septum (LS) is a basal forebrain GABAergic region that is implicated in social novelty. However, the neural circuits and cell signaling pathways that converge on the LS to mediate social behaviors aren't well understood. Multiple lines of evidence suggest that signaling of brain-derived neurotrophic factor (BDNF) through its receptor TrkB plays important roles in social behavior. BDNF is not locally produced in LS, but we demonstrate that nearly all LS GABAergic neurons express TrkB. Local TrkB knock-down in LS neurons decreased social novelty recognition and reduced recruitment of neural activity in LS neurons in response to social novelty. Since BDNF is not synthesized in LS, we investigated which inputs to LS could serve as potential BDNF sources for controlling social novelty recognition. We demonstrate that selectively ablating inputs to LS from the basolateral amygdala (BLA), but not from ventral CA1 (vCA1), impairs social novelty recognition. Moreover, depleting BDNF selectively in BLA-LS projection neurons phenocopied the decrease in social novelty recognition caused by either local LS TrkB knockdown or ablation of BLA-LS inputs. These data support the hypothesis that BLA-LS projection neurons serve as a critical source of BDNF for activating TrkB signaling in LS neurons to control social novelty recognition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.