ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2023
Male-selective effects of oxytocin agonism on alcohol intake: behavioral assessment in socially housed prairie voles and involvement of RAGE.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 15 citations in OpenAlex.
- Intranasal oxytocin blunts amygdala response to negative affective stimuli in males and females with alcohol use disorder: a randomized controlled cross-over trial.Psychopharmacology · 2025Trial
- Article
- Intranasal Vasopressin Decreases Voluntary Ethanol Drinking in Single- and Group-Housed Mice Through Mechanisms Involving Vasopressin 1a and 1b Receptors.Alcohol, clinical & experimental research · 2026Article
- Intranasal vasopressin, but not oxytocin, decreases ethanol intake in socially housed mice.Psychopharmacology · 2026Article
- Selective effects of oxytocin on alcohol drinking in subpopulations of male and female mice following intermittent predator stress.Alcohol and alcoholism (Oxford, Oxfordshire) · 2025Article
- Emerging medications and pharmacological treatment approaches for substance use disorders.Pharmacology, biochemistry, and behavior · 2025Review
- Analgesic effect of oxytocin in alcohol-dependent male and female rats.Alcohol (Fayetteville, N.Y.) · 2025Article
- Effects of oxytocin receptor agonists on hair growth promotion.Scientific reports · 2024Article
- Oxytocin decreases alcohol self-administration in male baboons.Translational psychiatry · 2024Article
- Effects of oxytocin receptor agonism on acquisition and expression of pair bonding in male prairie voles.Translational psychiatry · 2024Article
- The ReCoDe addiction research consortium: Losing and regaining control over drug intake-Findings and future perspectives.Addiction biology · 2024Review
- Effects of Oxytocin Receptor Agonism on Acquisition and Expression of Pair Bonding in Male Prairie Voles.Research square · 2024Article
- Intranasal oxytocin does not change partner preference in female titi monkeys (Plecturocebus cupreus), but intranasal vasopressin decreases it.Journal of neuroendocrinology · 2023Article
- Oxytocin Attenuates Yohimbine-Induced Reinstatement of Alcohol-Seeking in Female Rats via the Central Amygdala.Behavioral sciences (Basel, Switzerland) · 2023Article
- Sex-dependent divergence in the effects of GLP-1 agonist exendin-4 on alcohol reinforcement and reinstatement in C57BL/6J mice.Psychopharmacology · 2023Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Targeting the oxytocin (OXT) peptide system has emerged as a promising new approach for the treatment of alcohol use disorder (AUD). However, further advancements in this development depend on properly modeling various complex social aspects of AUD and its treatment. Here we examined behavioral and molecular underpinnings of OXT receptor (OXTR) agonism in prairie voles, a rodent species with demonstrated translational validity for neurobiological mechanisms regulating social affiliations. To further improve translational validity of these studies, we examined effects of intranasal (IN) OXT administration in male and female prairie voles socially housed in the presence of untreated cagemates. IN OXT selectively inhibited alcohol drinking in male, but not female, animals. Further, we confirmed that exogenously administered OXT penetrates the prairie vole brain and showed that Receptor for Advanced Glycation End-products assists this penetration after IN, but not intraperitoneal (IP), OXT administration. Finally, we demonstrated that IP administration of LIT-001, a small-molecule OXTR agonist, inhibits alcohol intake in male, but not female, prairie voles socially housed in the presence of untreated cagemates. Taken together, results of this study support the promise of selectively targeting OXTR for individualized treatment of AUD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.