SynthesisEuropean journal of pediatrics2023
Obesity as a risk factor for severe influenza infection in children and adolescents: a systematic review and meta-analysis.
Synthesis in European journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Pooled it
- Adrenomedullin is a good marker of severity and prognosis in patients with bronchiolitis.European journal of pediatrics · 2026Observational
- The Economic and Clinical Burden of Pediatric Obesity Within a Universal Health Coverage System in Thailand: A 9-Year Nationwide Analysis of 14.5 Million Hospitalizations.Diseases (Basel, Switzerland) · 2026Article
- Biological sex differences after high and low doses of influenza A virus infection during obesity.Frontiers in immunology · 2026Article
- Clinical practice guidelines for the treatment and prophylaxis of influenza in China (2025 edition).Infectious diseases & immunity · 2026Article
- Regional Implications of the COVID-19 Pandemic on Childhood Obesity Prevalence, Denver, Colorado, 2019-2022.Childhood obesity (Print) · 2025Article
- Acute Phase Extrapulmonary Effects of a High-Dose Influenza A Virus Infection in a Mouse Model of Obesity.Zoonotic diseases (Basel, Switzerland) · 2025Article
- Biological Sex Differences after High and Low Doses of Influenza A Virus Infection in a Diet-induced Obesity Mouse Model.bioRxiv : the preprint server for biology · 2025Article
- Females with Obesity Exhibit Greater Influenza Vaccine-induced Immunity and Protection than Males in a Mouse Model.bioRxiv : the preprint server for biology · 2025Article
- Prevalence of pneumococcal carriage and risk factors for pneumonia and carriage among under-5 children in Malaysia: findings from the MY-Pneumo study.Pneumonia (Nathan Qld.) · 2025Article
- Obesity is a growing problem and a modifiable factor affecting lung health.Pediatric research · 2025Article
- Nutrition, Lifestyle, and Environmental Factors in Lung Homeostasis and Respiratory Health.Nutrients · 2025Review
- The intersection of influenza infection and autoimmunity.Frontiers in immunology · 2025Review
- Article
- Females with obesity exhibit greater influenza vaccine-induced immunity and protection than males in a mouse model.Frontiers in immunology · 2025Article
- Human miR-1 Stimulates Metabolic and Thermogenic-Related Genes in Adipocytes.International journal of molecular sciences · 2024Article
- Elevated body mass index is not significantly associated with reduced influenza vaccine effectiveness.Scientific reports · 2024Article
- Article
- Evaluation of disease severity and prediction of severe cases in children hospitalized with influenza A (H1N1) infection during the post-COVID-19 era: a multicenter retrospective study.BMC pediatrics · 2024Article
- Regulatory T cells and bioenergetics of peripheral blood mononuclear cells linked to pediatric obesity.Immunometabolism (Cobham, Surrey) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity has been recently identified as a predisposing factor for a worse prognosis in viral illnesses such as SARS-CoV-2; however, its role in children with influenza is not yet clarified. The current systematic review and meta-analysis aims to assess whether obesity is a risk factor for either hospitalization or a worse prognosis when hospitalized among children infected by influenza. We systematically searched the following databases using a structured algorithm: MEDLINE, Clinicaltrials.gov, and Cochrane Central Register of Controlled Trials (CENTRAL). Statistical meta-analysis was performed using the "meta" package in R software, and included studies were evaluated using the Newcastle-Ottawa scale. Among children with influenza, obesity increased the odds of hospitalization with a pooled OR of 1.89 (95% CI [1.23, 2.9], I
conclusionsThe findings of our meta-analysis suggest that obesity in children with influenza is associated with a worse prognosis, both hospitalization and ICU admission/death. WHAT IS KNOWN: • Obesity has been identified as a risk factor for non-communicable as well as communicable diseases. • A previous meta-analysis failed to demonstrate a statistically significant association between obesity and influenza infection severity. WHAT IS NEW: • Children with high BMI and influenza infection are more likely to get hospitalized. • Pediatric inpatients with increased BMI and influenza infection may have a worse prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.