ArticleScientific reports2022
An open-source LED array illumination system for automated multiwell plate cell culture photodynamic therapy experiments.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Article
- An automated illumination system for high-throughput photopharmacology studies: a case study of ROS-sensitive Zn- and Pd-phthalocyanine-loaded liposomes.The Analyst · 2025Article
- Photodynamic Therapy Using a Rose-Bengal Photosensitizer for Hepatocellular Carcinoma Treatment: Proposition for a Novel Green LED-Based Device for In Vitro Investigation.Biomedicines · 2024Article
- In Vitro Antimicrobial Photodynamic Therapy forPharmaceutics · 2024Article
- Methods for assessing and removing non-specific photoimmunotherapy damage in patient-derived tumor cell culture models.Photochemistry and photobiologyArticle
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Authors and funding
5 authors.
Funding
Abstract
Photodynamic therapy (PDT) research would benefit from an automated, low-cost, and easy-to-use cell culture light treatment setup capable of illuminating multiple well replicates within standard multiwell plate formats. We present an LED-array suitable for performing high-throughput cell culture PDT experiments. The setup features a water-cooling loop to keep the LED-array temperature nearly constant, thus stabilizing the output power and spectrum. The setup also features two custom-made actuator arms, in combination with a pulse-width-modulation (PWM) technique, to achieve programmable and automatic light exposures for PDT. The setup operates at ~ 690 nm (676-702 nm, spectral output full-width half-maximum) and the array module can be readily adapted to other LED wavelengths. This system provides an illumination field with adjustable irradiance up to 400 mW/cm
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