Evidence map›Paper›PMID 36369308›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

Nomogram for the acute exacerbation of acetylcholine receptor antibody-positive generalized myasthenia gravis.

Jiaxin Chen, Shiyin Li, Li Feng, Haiyan Wang, Xin Huang, Huiyu Feng

Abstract read
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jiaxin Chen *Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Shiyin Li *Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Li FengDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Haiyan WangDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Xin HuangDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. huangx82@mail.sysu.edu.cn.
Huiyu FengDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. fenghuiy@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-1153-5919
Sun Yat-sen University · CN

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2020A1515110909Natural Science Foundation of Guangdong Province 2022A1515010478
6 · The paper itself

Abstract

BACKGROUND AND

objectiveAn acute exacerbation of myasthenia gravis (MG) can lead to the life-threatening myasthenia crisis which can increase the in-hospital mortality. This study aimed to clarify the correlative factor of the severity and activity of MG and the predictors of its exacerbation.

methodsA prospective study was conducted to compare the clinical characteristics of acetylcholine receptor antibody (AChR-Ab)-positive generalized MG during acute exacerbation (AE) and in a stable state (SS). Logistic regression was used to determine risk factors, and a nomogram was developed.

resultsA total of 97 AChR-Ab MG patients were enrolled, of whom 44 had AE and 53 were in SS. The concentrations of AChR-Ab were 35.24 (23.26, 42.52) nmol/L and 19.51 (8.30, 36.93) nmol/L in the AE and SS groups (P = 0.005), respectively. The receiver operating characteristic curve showed that a single AChR-Ab predicted severity and acute exacerbation, with an area under the curve (AUC) of 0.679. Logistic regression analysis showed that, in addition to AChR-Ab (P = 0.018), bulbar symptoms (P = 0.001), interleukin (IL)-6 (P = 0.025), CD4

conclusionAChR-Ab concentration was positively correlated with the severity and activity of MG. AChR-Ab concentration, alongside bulbar symptoms, IL-6 concentration, CD4

Indexed as

Myasthenia GravisNomogramsAutoantibodiesHumansProspective StudiesReceptors, CholinergicAutoantibodiesReceptors, CholinergicAcute exacerbationImpending myasthenia crisisMyasthenia gravisPredict model

Identifiers

PMID36369308
OpenAlexW4308834466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.