Evidence map›Paper›PMID 36369294›Full record

ReviewTranslational stroke research2023

Revisiting Transcranial Light Stimulation as a Stroke Therapeutic-Hurdles and Opportunities.

Wuwei Feng, Alexis Domeracki, Christine Park, Shreyansh Shah, Pratik Y Chhatbar, Swaroop Pawar, Cherylee Chang, Po-Chun Hsu, Eric Richardson, David Hasan and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational stroke research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Wuwei FengDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA. wayne.feng@duke.edu.ORCID http://orcid.org/0000-0001-6230-4905
Alexis DomerackiDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.
Christine ParkDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.
Shreyansh ShahDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.
Pratik Y ChhatbarDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.
Swaroop PawarDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.
Cherylee ChangDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.
Po-Chun HsuDepartment of Biomedical Engineering, Duke University, Durham, NC, 27710, USA.
Eric RichardsonDepartment of Biomedical Engineering, Duke University, Durham, NC, 27710, USA.
David HasanDepartment of Neurosurgery, Duke University School of Medicine, Durham, NC, 27710, USA.
Estate SokhadzeDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.
Quanguang ZhangDepartment Department of Neurology, LSU Health Sciences Center, Shreveport, LA, 71103, USA.
Hanli LiuDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX, 76019, USA.
Duke University · USLouisiana State University Health Sciences Center Shreveport · USThe University of Texas at Arlington · US

Funding

Novel Neuromodulation by Transcranial Infrared Brain Stimulation with ImagingRF1MH114285 · NIMH · UNIVERSITY OF TEXAS ARLINGTON · PI GONZALEZ-LIMA, FRANCISCO, LIU, HANLI · 2017 to 2017
$2.9M
Digital biomarkers for Alzheimer's Disease with compact dual-mode brain sensingR21AG079309 · NIA · UNIVERSITY OF TEXAS ARLINGTON · PI LIU, HANLI · 2022 to 2022
$388k
NIA NIH HHS R21 AG079309NIMH NIH HHS RF1 MH114285NIMH NIH HHS RF1MH114285
6 · The paper itself

Abstract

Near-infrared laser therapy, a special form of transcranial light therapy, has been tested as an acute stroke therapy in three large clinical trials. While the NEST trials failed to show the efficacy of light therapy in human stroke patients, there are many lingering questions and lessons that can be learned. In this review, we summarize the putative mechanism of light stimulation in the setting of stroke, highlight barriers, and challenges during the translational process, and evaluate light stimulation parameters, dosages and safety issues, choice of outcomes, effect size, and patient selection criteria. In the end, we propose potential future opportunities with transcranial light stimulation as a cerebroprotective or restorative tool for future stroke treatment.

Indexed as

Brain IschemiaLaser TherapyStrokeStroke RehabilitationHumansTranscranial Magnetic StimulationCerebroprotectionIschemic strokeNear-infrared laser therapyNoninvasive brain stimulationStroke recoveryTranscranial light stimulation

Identifiers

PMID36369294
PMCPMC13523026
OpenAlexW4308834650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.