ArticleNature communications2022
Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
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Authors and funding
49 authors at 8 institutions in 4 countries.
Kan XieTranslational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
Helmut FuchsInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-5143-2677
Enzo ScifoTranslational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0002-0450-6573
Dan LiuPopulation Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
Ahmad AzizPopulation Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0001-6184-458X
Juan Antonio Aguilar-PimentelInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-4694-7107
Oana Veronica AmarieInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-1705-6812
Lore BeckerInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-6890-4984
Patricia da Silva-ButtkusInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Julia Calzada-WackInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Yi-Li ChoInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Yushuang DengTranslational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
A Cole EdwardsTranslational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
Lillian GarrettInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Christina GeorgopoulouTranslational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0003-3861-5097
Raffaele GerliniInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-0852-5621
Sabine M HölterInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-4878-5241
Tanja Klein-RodewaldInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Michael KramerGEMoaB GmbH, Tatzberg 47, 01307, Dresden, Germany.
Stefanie LeuchtenbergerInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Dimitra LountziTranslational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
Phillip Mayer-KuckukInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Lena L NoverTranslational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
Manuela A OestereicherInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Clemens OverkottTranslational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
Brandon L PearsonTranslational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0003-4807-137X
Birgit RathkolbInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-1239-0547
Jan RozmanInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-8035-8904
Jenny RussNuclear Function Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0001-6550-761X
Kristina SchaafTranslational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
Nadine SpielmannInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Adrián Sanz-MorenoInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-9478-5432
Claudia StoegerInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Irina TreiseInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Daniele BanoAging and Neurodegeneration Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0002-9617-5504
Dirk H BuschInstitute for Medical Microbiology, Immunology, and Hygiene, Technische Universität München, 81675, Munich, Germany.ORCID http://orcid.org/0000-0001-8713-093X
Jochen GrawInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-0298-9660
Martin KlingensporMolecular Nutritional Medicine, Else Kröner-Fresenius Center, Technische Universität München, 85350, Freising-Weihenstephan, Germany.ORCID http://orcid.org/0000-0002-4502-6664
Thomas KlopstockFriedrich-Baur-Institut, Department of Neurology, Ludwig-Maximilians-University Munich, 80336, Munich, Germany.ORCID http://orcid.org/0000-0003-2805-4652
Beverly A MockLaboratory of Cancer Biology and Genetics, CCR, NCI, NIH, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0003-2479-4549
Paolo SalomoniNuclear Function Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0001-6885-8116
Carsten Schmidt-WeberCenter of Allergy & Environment (ZAUM), Technische Universität München, and Helmholtz Zentrum München, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-3203-8084
Marco WeiergräberResearch Group Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 53175, Bonn, Germany.
Eckhard WolfInstitute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University Munich, Munich, Germany.
Wolfgang WurstInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-4422-7410
Valérie Gailus-DurnerInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-6076-0111
Monique M B BretelerPopulation Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0002-0626-9305
Martin Hrabě de Angelis *Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-7898-2353
Dan Ehninger *Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany. Dan.Ehninger@dzne.de.ORCID http://orcid.org/0000-0001-7464-1335
Helmholtz Zentrum München · DEGerman Center for Neurodegenerative Diseases · DEUniversity of Bonn · DEFederal Institute for Drugs and Medical Devices · DEFresenius (Germany) · DEGesellschaft für Mikroelektronikanwendung Chemnitz (Germany) · DEInstitute of Medical Microbiology and Hygiene · DELudwig-Maximilians-Universität München · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current concepts regarding the biology of aging are primarily based on studies aimed at identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging can be of limited value because it may be restricted by specific pathologies. Here, we employ large-scale phenotyping to analyze hundreds of markers in aging male C57BL/6J mice. For each phenotype, we establish lifetime profiles to determine when age-dependent change is first detectable relative to the young adult baseline. We examine key lifespan regulators (putative anti-aging interventions; PAAIs) for a possible countering of aging. Importantly, unlike most previous studies, we include in our study design young treated groups of animals, subjected to PAAIs prior to the onset of detectable age-dependent phenotypic change. Many PAAI effects influence phenotypes long before the onset of detectable age-dependent change, but, importantly, do not alter the rate of phenotypic change. Hence, these PAAIs have limited effects on aging.
Indexed as
AgingLongevityAnimalsMaleMiceMice, Inbred C57BLPhenotype
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