ArticleNature communications2022
Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
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- Global diversity of integrating conjugative elements (ICEs) inbioRxiv : the preprint server for biology · 2025Article
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- Genome-wide accumulations of non-random adaptive point mutations drive westward evolution of Helicobacter pylori.BMC microbiology · 2025Article
- Prophage dynamics in gastric and enterohepatic environments: unraveling ecological barriers and adaptive transitions.ISME communications · 2025Article
- An ancient ecospecies of Helicobacter pylori.Nature · 2024Article
- Whole-genome sequencing analyses and antibiotic resistance situation of 48 Helicobacter pylori strains isolated in Zhejiang, China.Gut pathogens · 2024Article
- A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation.Signal transduction and targeted therapy · 2024Review
- Genomic insights into the antimicrobial resistance and virulence of Helicobacter pylori isolates from gastritis patients in Pereira, Colombia.BMC genomics · 2024Article
- A Prototype of Graphene E-Nose for Exhaled Breath Detection and Label-Free Diagnosis of Helicobacter Pylori Infection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Global spread of Salmonella enterica due to centralized industrialization of pig farming.Nature food · 2024Article
- The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes.Nature communications · 2023Article
- Methylome evolution suggests lineage-dependent selection in the gastric pathogen Helicobacter pylori.Communications biology · 2023Article
- Pathogenomics of Helicobacter pylori.Current topics in microbiology and immunology · 2023Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
24 authors at 16 institutions in 13 countries.
Funding
Abstract
Helicobacter pylori lives in the human stomach and has a population structure resembling that of its host. However, H. pylori from Europe and the Middle East trace substantially more ancestry from modern African populations than the humans that carry them. Here, we use a collection of Afro-Eurasian H. pylori genomes to show that this African ancestry is due to at least three distinct admixture events. H. pylori from East Asia, which have undergone little admixture, have accumulated many more non-synonymous mutations than African strains. European and Middle Eastern bacteria have elevated African ancestry at the sites of these mutations, implying selection to remove them during admixture. Simulations show that population fitness can be restored after bottlenecks by migration and subsequent admixture of small numbers of bacteria from non-bottlenecked populations. We conclude that recent spread of African DNA has been driven by deleterious mutations accumulated during the original out-of-Africa bottleneck.
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