SynthesisEnvironmental health : a global access science source2022
Phthalates and bone mineral density: a systematic review.
Synthesis in Environmental health : a global access science source, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Exploring the relationship between microplastic exposure and bone health.Endocrine connections · 2026Review
- Long-term association between phthalate exposure in pregnancy and midlife bone mineral density among women in Mexico City.Environmental health : a global access science source · 2026Article
- Exposure to polylactic acid microplastics during puberty increases the risk of skeletal dysplasia by disrupting arachidonic acid metabolism in osteoblasts.Particle and fibre toxicology · 2026Article
- Network Toxicology and Molecular Docking Reveal the Toxicological Mechanisms of DEHP in Bone Diseases.International journal of molecular sciences · 2025Article
- Effects of Endocrine-Disrupting Chemicals on Bone Health.Endocrinology and metabolism (Seoul, Korea) · 2024Review
- Association between diabetes mellitus and trochanteric bone mineral density in individuals with osteoporotic fractures: a retrospective study.Frontiers in medicine · 2024Article
- Role of mitochondrial disruption and oxidative stress in plasticizer phthalate-induced cytotoxicity to human bone osteoblasts.Toxicology research · 2023Article
- Developmental exposures to common environmental contaminants, DEHP and lead, alter adult brain and blood hydroxymethylation in mice.Frontiers in cell and developmental biology · 2023Article
- Endocrine Society of India's National White Paper on Endocrine Disrupting Chemicals - A Call for Action.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to endocrine disruptors, such as phthalates, may impact bone mineral density (BMD) through a variety of mechanisms. Studies of phthalate exposure and BMD in humans are scarce.
objectivesTo synthesize published data on the association between phthalate metabolites and BMD in humans and to provide methodological suggestions for future research.
methodsA single investigator searched PubMed for relevant studies, including observational studies of phthalate exposure and BMD in children and postmenopausal women. Twelve studies were screened with 5 meeting the eligibility criteria and included for review. A quality assessment form was used as a quality measure and key information was extracted from the included studies.
resultsIn one prospective study among postmenopausal women, higher levels of monocarboxyoctyl phthalate (MCOP) and monocarboxynonyl phthalate (MCNP) were significantly associated with lower BMD among nonusers of hormone therapy (HT). In cross-sectional studies of postmenopausal women, monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono (3-carboxypropyl) phthalate (MCPP), and mono-benzyl phthalate (MBzP) were negatively associated with BMD, and MCNP was positively associated with BMD, but these results were not replicated across studies. In studies of fetal exposure to phthalates and childhood BMD, significant positive associations between MCPP and BMD in children at age 12 years were found in 1 study, while associations were null in the other study.
conclusionsStudies among postmenopausal women provide suggestive evidence of an association between urinary phthalate metabolite concentration and decreased BMD. Results from studies of childhood BMD are inconclusive given the limited data and their limitations. More research is needed to address limitations and further investigate the association between phthalate exposure and human BMD.
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Registered trials
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