Evidence map›Paper›PMID 36368988›Full record

ArticleImmunity & ageing : I & A2022

Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8

Jian Lu, Guobing Chen, Arina Sorokina, Thomas Nguyen, Tonya Wallace, Cuong Nguyen, Christopher Dunn, Stephanie Wang, Samantha Ellis, Guixin Shi and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity & ageing : I & A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Jian Lu *Laboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, USA.
Guobing Chen *Laboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, USA.
Arina SorokinaLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, USA.
Thomas NguyenLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, USA.
Tonya WallaceLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, USA.
Cuong NguyenLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, USA.
Christopher DunnLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, USA.
Stephanie WangLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, USA.
Samantha EllisLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, USA.
Guixin ShiDiagnologix LLC, San Diego, CA, USA.
Julia McKelveyApheresis Unit, Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD, USA.
Alexei SharovLaboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA.
Yu-Tsueng LiuDiagnologix LLC, San Diego, CA, USA.
Jonathan SchneckDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nan-Ping WengLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD, USA. Wengn@mail.nih.gov.
National Institute on Aging · USDiagnologix (United States) · USJohns Hopkins University · USUniversity of California, San Diego · US

Funding

Toward GMP production of antigen specific regulatory T cellsR44CA265468 · NCI · DIAGNOLOGIX, LLC · PI SHI, GUIXIN · 2021 to 2023
$2.3M
NCI NIH HHS R44 CA265468
6 · The paper itself

Abstract

backgroundCytomegalovirus (CMV) infection leads to effector memory CD8

resultsWe compared CD8

conclusionOur findings showed that CMV infection causes mild expansion of CMV-NLV-specific CD8

Indexed as

ActivationCD70Chronic infectionCMV-specific CD8+ T cellsExpansion

Identifiers

PMID36368988
PMCPMC9650803
OpenAlexW4308915459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.