Trial reportBMC psychiatry2022
Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial.
Trial report in BMC psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03766074 (Evaluation of Vitamin D Supplementation Effects on Serum 25), which is not on this map. Cited by 24 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Vitamin D Supplementation Effects on Serum 25(OH)D3, PTH, Pro-inflammatory Biomarkers and Neurotransmitters Involved in Depression, and Depression Status in Depressive Patients
Who cites it
24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Nutraceuticals and phytoceuticals for the treatment of major depressive disorder: a systematic review and network meta-analysis.Molecular psychiatry · 2026Pooled it
- Adherence to the MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet and depression, stress, and anxiety: a systematic review.BMC nutrition · 2026Pooled it
- Efficacy of vitamin D supplementation in patients diagnosed with depression: a dose-response meta-analysis of randomized controlled trials.Frontiers in nutrition · 2026Pooled it
- Understanding the research landscape of over-the-counter herbal products, dietary supplements, and medications evaluated for depressive symptoms in adults: a scoping review.Frontiers in pharmacology · 2025Pooled it
- Nutraceuticals in Psychiatric Disorders: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- The efficacy and safety of complementary and alternative medicine for depression: an umbrella review.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2024Pooled it
- Does inflammation moderate the effect of vitamin D supplementation on depressive symptoms? Results of an interventional study in children and adolescents.European journal of nutrition · 2026Trial
- Trial
- Vitamin D Deficiency and 3-Year Risk of New-Onset Depression After Metabolic and Bariatric Surgery: A Longitudinal Cohort Study.Obesity surgery · 2026Article
- Vitamin D as a Lifespan Neuroimmune Signal in Psychiatry: From Developmental Risk to Precision Nutrition.Nutrients · 2026Review
- Vitamin D and Vitamin BDiseases (Basel, Switzerland) · 2026Review
- Effects of vitamin D supplementation on depression in adult women: a systematic review of randomized controlled trials.Journal of Korean biological nursing science · 2026Review
- Vitamin D neuroimmune synaptic plasticity and precision intervention in pediatric neurodevelopmental disorders.Frontiers in aging neuroscience · 2026Review
- The Role of Vitamin D in the Management of Major Depressive Disorder: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Vitamin D, B9, and B12 Deficiencies as Key Drivers of Clinical Severity and Metabolic Comorbidities in Major Psychiatric Disorders.Nutrients · 2025Article
- Efficacy of Serum BDNF for the Evaluation of Depressive Neurological Symptoms in Patients with Refractory Ulcerative Colitis.Journal of clinical medicine · 2025Article
- Meta-analysis of the effect of vitamin D on depression.Frontiers in psychiatry · 2025Review
- Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health.International journal of molecular sciences · 2024Review
- The Pathologic Roles and Therapeutic Implications of Ghrelin/GHSR System in Mental Disorders.Depression and anxiety · 2024Review
- Vitamin D Deficiency Participates in Depression of Patients with Diabetic Peripheral Neuropathy by Regulating the Expression of Pro-Inflammatory Cytokines.Neuropsychiatric disease and treatment · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth augmented inflammatory reaction and low vitamin D status are associated with depression but the magnitude of their relationships is unclear. This study was, therefore, conducted to evaluate the effects of vitamin D supplementation on serum 25(OH)D concentration, depression severity and some pro-inflammatory biomarkers in patients with mild to moderate depression.
methodsAn 8-week double-blind randomized clinical trial (RCT) was performed on 56 (18-60 yrs) patients with mild to moderate depression, randomly assigned to intervention (50,000 IU cholecalciferol 2wks
resultsAt the end point, statistically significant changes were observed only in intervention group as compared with controls including increased 25(OH)D concentration (+ 40.83 ± 28.57 vs. + 5.14 ± 23.44 nmol L
conclusionIncreased circulating 25(OH)D concentrations following 8-week vitamin D supplementation (50,000 IU 2wks
trial registrationThe clinical trial registration code was obtained from the Iranian Registry of Clinical Trials (date of registration: 17/09/2018, registration number: IRCT20170926036425N1) and ClinicalTrials.gov (date of registration: 04/12/2018, registration number: NCT03766074).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.