ArticleCerebral cortex (New York, N.Y. : 1991)2023
Spectral specificity of gamma-frequency transcranial alternating current stimulation over motor cortex during sequential movements.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Effects of transcranial alternating current stimulation on neurophysiologic motor function in Parkinson's patients: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Article
- Magnetoencephalography in human neuroscience research: planning, piloting, implementation and quality assurance.Nature protocols · 2026Review
- Bifocal Beta-frequency Transcranial Alternating Current Stimulation Enhances Somatosensory Spatial Discrimination.Brain topography · 2026Article
- High-definition tDCS of the motor cortex affects prefrontal and primary motor activity differently in young and older adults.GeroScience · 2026Article
- Transcranial alternating current stimulation improves ballistic motor performance in trained and untrained limbs of healthy older adults.GeroScience · 2026Article
- Variable E-field properties of dual-site tACS with phase lags.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Dual-montage high-definition transcranial direct current stimulation (HD-tDCS) modulates the neural dynamics serving working memory.NeuroImage · 2025Article
- Developmental trajectory of neural activity underlying motor control differs by sequence complexity and motor stage.NeuroImage · 2025Article
- Motor-Related Neural Dynamics are Modulated by Regular Cannabis Use Among People with HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- High-definition transcranial direct-current stimulation of left primary motor cortices modulates beta and gamma oscillations serving motor control.The Journal of physiology · 2025Article
- Gamma Transcranial Alternating Current Stimulation Has Frequency-Dependent Effects on Human Motor Cortex Plasticity Induced by Theta-Burst Stimulation.The European journal of neuroscience · 2025Article
- The polarity of high-definition transcranial direct current stimulation affects the planning and execution of movement sequences.NeuroImage · 2025Article
- Human cortical high-gamma power scales with movement rate in healthy participants and stroke survivors.The Journal of physiology · 2025Article
- Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation.NPJ Parkinson's disease · 2025Review
- Modulating Cortico-cortical Networks with Transcranial Alternating Current Stimulation: A Minireview.Physical therapy research · 2025Review
- Regular cannabis use modulates gamma activity in brain regions serving motor control.Journal of psychopharmacology (Oxford, England) · 2024Article
- Advances in Non-Invasive Neuromodulation Techniques for Improving Cognitive Function: A Review.Brain sciences · 2024Review
- Article
- Personalized strategies of neurostimulation: from static biomarkers to dynamic closed-loop assessment of neural function.Frontiers in neuroscience · 2024Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Motor control requires the coordination of spatiotemporally precise neural oscillations in the beta and gamma range within the primary motor cortex (M1). Recent studies have shown that motor performance can be differentially modulated based on the spectral target of noninvasive transcranial alternating current stimulation (tACS), with gamma-frequency tACS improving motor performance. However, the spectral specificity for eliciting such improvements remains unknown. Herein, we derived the peak movement-related gamma frequency in 25 healthy adults using magnetoencephalography and a motor control paradigm. These individualized peak gamma frequencies were then used for personalized sessions of tACS. All participants completed 4 sessions of high-definition (HD)-tACS (sham, low-, peak-, and high-gamma frequency) over M1 for 20 min during the performance of sequential movements of varying complexity (e.g. tapping adjacent fingers or nonadjacent fingers). Our primary findings demonstrated that individualized tACS dosing over M1 leads to enhanced motor performance/learning (i.e. greatest reduction in time to complete motor sequences) compared to nonspecific gamma-tACS in humans, which suggests that personalized neuromodulation may be advantageous to optimize behavioral outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.