Evidence map›Paper›PMID 36368888›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2023

Cortical networks show characteristic recruitment patterns after somatosensory stimulation by pneumatically evoked repetitive hand movements in newborn infants.

Eero Ahtola, Susanna Leikos, Anna Tuiskula, Leena Haataja, Eero Smeds, Harri Piitulainen, Veikko Jousmäki, Anton Tokariev, Sampsa Vanhatalo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Eero AhtolaDepartment of Clinical Neurophysiology, BABA Center, Pediatric Research Center, Children's Hospital and HUS Diagnostics, Helsinki University Hospital and University of Helsinki, Helsinki, 00029 HUS, Finland.ORCID 0000-0002-0717-0809
Susanna LeikosDepartment of Clinical Neurophysiology, BABA Center, Pediatric Research Center, Children's Hospital and HUS Diagnostics, Helsinki University Hospital and University of Helsinki, Helsinki, 00029 HUS, Finland.
Anna TuiskulaDepartment of Clinical Neurophysiology, BABA Center, Pediatric Research Center, Children's Hospital and HUS Diagnostics, Helsinki University Hospital and University of Helsinki, Helsinki, 00029 HUS, Finland.
Leena HaatajaDepartment of Pediatric Neurology, Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, 00029 HUS, Finland.
Eero SmedsChildren's Hospital and Pediatric Research Center, Helsinki University Hospital and University of Helsinki, Helsinki, 00029 HUS, Finland.
Harri PiitulainenDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, 00076 AALTO, Finland.
Veikko JousmäkiAalto NeuroImaging, Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, 00076 AALTO, Finland.
Anton TokarievDepartment of Clinical Neurophysiology, BABA Center, Pediatric Research Center, Children's Hospital and HUS Diagnostics, Helsinki University Hospital and University of Helsinki, Helsinki, 00029 HUS, Finland.ORCID 0000-0002-1202-9981
Sampsa VanhataloDepartment of Clinical Neurophysiology, BABA Center, Pediatric Research Center, Children's Hospital and HUS Diagnostics, Helsinki University Hospital and University of Helsinki, Helsinki, 00029 HUS, Finland.ORCID 0000-0002-9771-7061
University of Helsinki · FIAalto University · FIUniversity of Jyväskylä · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Controlled assessment of functional cortical networks is an unmet need in the clinical research of noncooperative subjects, such as infants. We developed an automated, pneumatic stimulation method to actuate naturalistic movements of an infant's hand, as well as an analysis pipeline for assessing the elicited electroencephalography (EEG) responses and related cortical networks. Twenty newborn infants with perinatal asphyxia were recruited, including 7 with mild-to-moderate hypoxic-ischemic encephalopathy (HIE). Statistically significant corticokinematic coherence (CKC) was observed between repetitive hand movements and EEG in all infants, peaking near the contralateral sensorimotor cortex. CKC was robust to common sources of recording artifacts and to changes in vigilance state. A wide recruitment of cortical networks was observed with directed phase transfer entropy, also including areas ipsilateral to the stimulation. The extent of such recruited cortical networks was quantified using a novel metric, Spreading Index, which showed a decrease in 4 (57%) of the infants with HIE. CKC measurement is noninvasive and easy to perform, even in noncooperative subjects. The stimulation and analysis pipeline can be fully automated, including the statistical evaluation of the cortical responses. Therefore, the CKC paradigm holds great promise as a scientific and clinical tool for controlled assessment of functional cortical networks.

Indexed as

MagnetoencephalographyMovementBiomechanical PhenomenaElectroencephalographyHandHumansInfantInfant, Newborncorticokinematic coherenceEEGfunctional networkspassive movement stimulationperinatal asphyxia

Identifiers

PMID36368888
PMCPMC10110426
OpenAlexW4308834966

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.