Evidence map›Paper›PMID 36368750›Full record

ArticleBMJ open2022

Optimisation of treatments for oral

Fabian Y S Kong, Magnus Unemo, Shueh H Lim, Ngaire Latch, Deborah A Williamson, Jason A Roberts, Steven C Wallis, Suzanne L Parker, Cornelia B Landersdorfer, Tami Yap and 5 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Molecular epidemiology and pharmacokinetic-pharmacodynamic analysis of Neisseria gonorrhoeae strains in Northern Spain.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 4 countries.

Fabian Y S KongCentre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia kongf@unimelb.edu.au.ORCID 0000-0002-9349-3080
Magnus UnemoWHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for Sexually Transmitted Infections, Department of Laboratory Medicine, Microbiology, Örebro University, Orebro, Sweden.
Shueh H LimCentre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Ngaire LatchCentre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Deborah A WilliamsonDepartment of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.
Jason A RobertsThe University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia.
Steven C WallisThe University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia.
Suzanne L ParkerThe University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia.
Cornelia B LandersdorferMonash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Tami YapMelbourne Dental School, The University of Melbourne, Melbourne, Victoria, Australia.
Christopher K FairleyMelbourne Sexual Health Centre, Alfred Health, Carlton, Victoria, Australia.
Eric P F ChowMelbourne Sexual Health Centre, Alfred Health, Carlton, Victoria, Australia.
David A LewisWestmead Clinical School and Sydney Institute for Infectious Diseases, The University of Sydney, Sydney, New South Wales, Australia.
Mohamed A HammoudKirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Jane S HockingCentre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
The University of Melbourne · AUThe University of Queensland · AUMelbourne Sexual Health Centre · AUMonash University · AUÖrebro University · SEThe University of Sydney · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMETHODS AND ANALYSIS: Healthy male volunteers (participants) recruited into the study will receive single doses of either ceftriaxone 1 g, cefixime 400 mg or ceftriaxone 500 mg plus 2 g azithromycin. Participants will provide samples at 6-8 time points (treatment regimen dependent) from four oral sites, two oral fluids, one anorectal swab and blood. Participants will complete online questionnaires about their medical history, sexual practices and any side effects experienced up to days 5-7. Saliva/oral mucosal pH and oral microbiome analysis will be undertaken. Bioanalysis will be conducted by liquid chromatography-mass spectrometry. Drug concentrations over time will be used to develop mathematical models for optimisation of drug dosing regimens and to estimate pharmacodynamic targets of efficacy. ETHICS AND DISSEMINATION: This study was approved by Royal Melbourne Hospital Human Research Ethics Committee (60370/MH-2021). The study results will be submitted for publication in peer-reviewed journals and reported at conferences. Summary results will be sent to participants requesting them. All data relevant to the study will be included in the article or uploaded as supplementary information. TRIAL REGISTRATION NUMBER: ACTRN12621000339853.

Indexed as

GonorrheaAnti-Bacterial AgentsCefiximeCeftriaxoneClinical Trials as TopicHumansMaleNeisseria gonorrhoeaeAnti-Bacterial AgentsCefiximeCeftriaxoneCLINICAL PHARMACOLOGYINFECTIOUS DISEASESSEXUAL MEDICINE

Identifiers

PMID36368750
PMCPMC9660608
OpenAlexW4308797387

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.