Evidence map›Paper›PMID 36368524›Full record

SynthesisNeuroscience and biobehavioral reviews2022

Psychological distress and metabolomic markers: A systematic review of posttraumatic stress disorder, anxiety, and subclinical distress.

Yiwen Zhu, Shaili C Jha, Katherine H Shutta, Tianyi Huang, Raji Balasubramanian, Clary B Clish, Susan E Hankinson, Laura D Kubzansky

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuroscience and biobehavioral reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  14. Challenges in the End-of-Life Care for Patients With Severe Persistent Mental Illness: A Case Series.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yiwen ZhuDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: yiwenzhu@mail.harvard.edu.
Shaili C JhaDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: sjha@hsph.harvard.edu.
Katherine H ShuttaDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Tianyi HuangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Raji BalasubramanianDepartment of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.
Clary B ClishBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Susan E HankinsonDepartment of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.
Laura D KubzanskyDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Funding

Metabolomic profile of chronic distress in relation to diseases of aging across diverse populationsR01AG051600 · NIA · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Susan E Hankinson, LAURA D KUBZANSKY · 2017 to 2026
$4.9M
NIA NIH HHS R01 AG051600
6 · The paper itself

Abstract

Psychological distress can be conceptualized as an umbrella term encompassing symptoms of depression, anxiety, posttraumatic stress disorder (PTSD), or stress more generally. A systematic review of metabolomic markers associated with distress has the potential to reveal underlying molecular mechanisms linking distress to adverse health outcomes. The current systematic review extends prior reviews of clinical depressive disorders by synthesizing 39 existing studies that examined metabolomic markers for PTSD, anxiety disorders, and subclinical psychological distress in biological specimens. Most studies were based on small sets of pre-selected candidate metabolites, with few metabolites overlapping between studies. Vast heterogeneity was observed in study design and inconsistent patterns of association emerged between distress and metabolites. To gain a more robust understanding of distress and its metabolomic signatures, future research should include 1) large, population-based samples and longitudinal assessments, 2) replication and validation in diverse populations, 3) and agnostic metabolomic strategies profiling hundreds of targeted and nontargeted metabolites. Addressing these research priorities will improve the scope and reproducibility of future metabolomic studies of psychological distress.

Indexed as

Psychological DistressStress Disorders, Post-TraumaticAnxietyAnxiety DisordersDepressionHumansReproducibility of ResultsStress, PsychologicalAnxietyDepressive symptomsMetabolomicsPosttraumatic stress disorder (PTSD)Psychological distressSystematic review

Identifiers

PMID36368524
PMCPMC9729460

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.