Evidence map›Paper›PMID 36368298›Full record

ArticleDrug metabolism and pharmacokinetics2022

Effect of deuteration on the single dose pharmacokinetic properties and postoperative analgesic activity of methadone.

Xiao-Ming Wang, Jigong Wang, Valentina Fokina, Svetlana Patrikeeva, Erik Rytting, Mahmoud S Ahmed, Jun-Ho La, Tatiana Nanovskaya

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and pharmacokinetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiao-Ming WangMaternal-Fetal Pharmacology and Bio-Development Laboratories, Department of Obstetrics & Gynecology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Jigong WangDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Valentina FokinaMaternal-Fetal Pharmacology and Bio-Development Laboratories, Department of Obstetrics & Gynecology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Svetlana PatrikeevaMaternal-Fetal Pharmacology and Bio-Development Laboratories, Department of Obstetrics & Gynecology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Erik RyttingMaternal-Fetal Pharmacology and Bio-Development Laboratories, Department of Obstetrics & Gynecology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Mahmoud S AhmedMaternal-Fetal Pharmacology and Bio-Development Laboratories, Department of Obstetrics & Gynecology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Jun-Ho LaDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Tatiana NanovskayaMaternal-Fetal Pharmacology and Bio-Development Laboratories, Department of Obstetrics & Gynecology, University of Texas Medical Branch, Galveston, TX, 77555, USA. Electronic address: tnnanovs@utmb.edu.
The University of Texas Medical Branch at Galveston · US

Funding

Mechanisms of chronic pain maintained by ongoing nociceptor inputs in femalesR01NS112344 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LA, JUN-HO · 2019 to 2023
$1.7M
NINDS NIH HHS R01 NS112344
6 · The paper itself

Abstract

Although methadone is effective in the management of acute pain, the complexity of its absorption-distribution-metabolism-excretion profile limits its use as an opioid of choice for perioperative analgesia. Because deuteration is known to improve the pharmacokinetic, pharmacodynamic and toxicological properties of some drugs, here we characterized the single dose pharmacokinetic properties and post-operative analgesic efficacy of d

Indexed as

Analgesics, OpioidMethadoneAnimalsBlood-Brain BarrierBrainKineticsMaleMiceAnalgesics, OpioidMethadoned(9)-methadoneDeuterationMetabolismPharmacokineticPostoperative pain

Identifiers

PMID36368298
PMCPMC9886271
OpenAlexW4305082172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.