Evidence map›Paper›PMID 36368178›Full record

ArticleJournal of critical care2023

Admission serum sodium and osmolarity are not associated with the occurrence or outcomes of acute respiratory distress syndrome in critically ill.

Heyi Li, Shailesh Bihari, Timothy Weister, Allison LeMahieu, Rahul Kashyap, Sarah Chalmers, Amos Lal, Andrew Bersten, Ognjen Gajic

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of critical care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Heyi LiDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: li.heyi@mayo.edu.
Shailesh BihariIntensive Care Unit, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia; College of Medicine and Public Health, Flinders University, Bedford Park, South Australia 5042, Australia.
Timothy WeisterAnesthesia Clinical Research Unit, Mayo Clinic, Rochester, MN 55905, USA.
Allison LeMahieuDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Rochester, MN 55905, USA.
Rahul KashyapDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Sarah ChalmersDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Amos LalDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Andrew BerstenIntensive Care Unit, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia; College of Medicine and Public Health, Flinders University, Bedford Park, South Australia 5042, Australia.
Ognjen GajicDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Mayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies suggested that hypernatremia or hyperosmolarity may have protective effects in lung injury. We hypothesized that hypernatremia and/or hyperosmolarity would prevent ARDS.

designRetrospective cohort study of all admissions at medical, surgical, and multidisciplinary intensive care units in Mayo Clinic, Rochester from the year of 2009 to 2019. The occurrence of ARDS was identified using a validated computerized search strategy. The association between serum sodium/osmolarity and the occurrence of ARDS was analyzed using a multivariable logistic regression model. The relationship between serum sodium/osmolarity and outcomes of ARDS was analyzed using linear and logistic regression models.

resultsAmong 50,498 patients, the serum sodium level on admission did not have a significant association with the occurrence of ARDS, with an adjusted odds ratio of 0.95 [95% CI (0.86, 1.05)]. There was no significant association between calculated serum osmolarity and the occurrence of ARDS, with an adjusted odds ratio of 1.03 [95% CI (1.00, 1.07)]. 1560 patients developed ARDS during the ICU stay. Their serum sodium level and osmolarity level did not have a significant association with their outcomes.

conclusionsAdmission serum sodium or serum osmolarity were not associated with the occurrence or outcomes of ARDS in ICU.

Indexed as

HypernatremiaRespiratory Distress SyndromeCritical IllnessHumansIntensive Care UnitsOsmolar ConcentrationRetrospective StudiesSodiumSodiumAcute lung injuryARDSCritical careHypernatremiaHyperosmolarity

Identifiers

PMID36368178
PMCPMC9616514
OpenAlexW4308035124

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.