Evidence map›Paper›PMID 36368007›Full record

ArticleJournal of medicinal chemistry2022

Site-Specific Radiohalogenation of a HER2-Targeted Single-Domain Antibody Fragment Using a Novel Residualizing Prosthetic Agent.

Yutian Feng, Samantha M Sarrett, Rebecca L Meshaw, Ganesan Vaidyanathan, Mike A Cornejo, Brian M Zeglis, Michael R Zalutsky

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Preclinical evaluation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  3. Preclinical evaluation and pilot clinical study of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  4. Review
  5. Review
  6. Site-specific bioconjugation and nuclear imaging.Current opinion in chemical biology · 2024
    Review
  7. Review
  8. Recent advances in the development ofAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024
    Review
  9. RSC medicinal chemistry · 2024
    Article
  10. Radiosynthesis and preclinical evaluations of [American journal of nuclear medicine and molecular imaging · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yutian FengDepartment of Radiology, Duke University Medical Center, Durham, North Carolina 27710, United States.
Samantha M SarrettHunter College, City University of New York, New York, New York 10021, United States.
Rebecca L MeshawDepartment of Radiology, Duke University Medical Center, Durham, North Carolina 27710, United States.
Ganesan VaidyanathanDepartment of Radiology, Duke University Medical Center, Durham, North Carolina 27710, United States.ORCID 0000-0003-3041-8275
Mike A CornejoHunter College, City University of New York, New York, New York 10021, United States.
Brian M ZeglisHunter College, City University of New York, New York, New York 10021, United States.ORCID 0000-0002-9091-744X
Michael R ZalutskyDepartment of Radiology, Duke University Medical Center, Durham, North Carolina 27710, United States.ORCID 0000-0002-5456-0324
Duke Medical Center · USThe Graduate Center, CUNY · US

Funding

Pretargeted Clinical Imaging of CA19.9 in Pancreatic CancerU01CA221046 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ZEGLIS, BRIAN MATTHEW · 2018 to 2022
$3.5M
Novel Transgenic Mouse Models Addressing Outstanding Translational Barriers in Antibody-Based TherapeuticsR01CA244327 · NCI · ROCKEFELLER UNIVERSITY · PI BOURNAZOS, STYLIANOS · 2020 to 2024
$3.0M
Novel Reagents for Rapid and Stable Thiol-Based BioconjugationsR01CA240963 · NCI · HUNTER COLLEGE · PI ZEGLIS, BRIAN MATTHEW · 2019 to 2023
$1.6M
A PET Radiotracer for Diagnostic and Theranostics Imaging in Lyme DiseaseR21EB030275 · NIBIB · HUNTER COLLEGE · PI QIU, WEIGANG, ZEGLIS, BRIAN MATTHEW · 2020 to 2021
$429k
NCI NIH HHS R01 CA240963NCI NIH HHS R01 CA244327NCI NIH HHS U01 CA221046NIBIB NIH HHS R21 EB030275
6 · The paper itself

Abstract

Because of their rapid tumor accumulation and normal tissue clearance, single-domain antibody fragments (sdAbs) are an attractive vehicle for developing radiotherapeutics labeled with the α-emitter

Indexed as

Breast NeoplasmsSingle-Domain AntibodiesCell Line, TumorErb-b2 Receptor Tyrosine KinasesFemaleHumansRadiopharmaceuticalsTissue DistributionErb-b2 Receptor Tyrosine KinasesRadiopharmaceuticalsSingle-Domain Antibodies

Identifiers

PMID36368007
PMCPMC10244946
OpenAlexW4308792209

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.