Evidence map›Paper›PMID 36367893›Full record

ReviewMolecular reproduction and development2022

Structures and functions of cilia during vertebrate embryo development.

Jeffrey D Amack

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular reproduction and development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  9. Review
  10. Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jeffrey D AmackDepartment of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York, USA.ORCID 0000-0002-5465-9754
SUNY Upstate Medical University · US

Funding

Four-dimensional prediction and quantification of how physical forces impact organogenesis in zebrafishR01HD099031 · NICHD · SYRACUSE UNIVERSITY · PI AMACK, JEFFREY D, MANNING, MARY ELIZABETH LISA · 2020 to 2024
$2.1M
NICHD NIH HHS R01 HD099031
6 · The paper itself

Abstract

Cilia are hair-like structures that project from the surface of cells. In vertebrates, most cells have an immotile primary cilium that mediates cell signaling, and some specialized cells assemble one or multiple cilia that are motile and beat synchronously to move fluids in one direction. Gene mutations that alter cilia structure or function cause a broad spectrum of disorders termed ciliopathies that impact virtually every system in the body. A wide range of birth defects associated with ciliopathies underscores critical functions for cilia during embryonic development. In many cases, the mechanisms underlying cilia functions during development and disease remain poorly understood. This review describes different types of cilia in vertebrate embryos and discusses recent research results from diverse model systems that provide novel insights into how cilia form and function during embryo development. The work discussed here not only expands our understanding of in vivo cilia biology, but also opens new questions about cilia and their roles in establishing healthy embryos.

Indexed as

CiliaCiliopathiesAnimalsEmbryonic DevelopmentSignal TransductionVertebratesbirth defectsciliopathiesembryonic developmentmulticiliated cellsprimary cilia

Identifiers

PMID36367893
PMCPMC9805515
OpenAlexW4308773061

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.