Evidence map›Paper›PMID 36367688›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2022

Detrimental effects of transient cerebral ischemia on middle cerebral artery mitochondria in female rats.

Ibolya Rutkai, Ivan Merdzo, Sanjay Wunnava, Catherine McNulty, Partha K Chandra, Prasad V Katakam, David W Busija

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Mitochondria dysfunction, a potential cytoprotection target against ischemia-reperfusion injury in a mouse stroke model.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  3. Article
  4. Article
  5. Sex as a biological variable for cardiovascular physiology.American journal of physiology. Heart and circulatory physiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ibolya RutkaiDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.ORCID 0000-0001-6974-6386
Ivan MerdzoDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Sanjay WunnavaDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Catherine McNultyDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Partha K ChandraDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.ORCID 0000-0002-4396-3996
Prasad V KatakamDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
David W BusijaDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Tulane University · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Mitochondrial Influences on Cerebral ArteriesR01HL093554 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BUSIJA, DAVID W · 2009 to 2018
$3.3M
Peroxynitrite is a Molecular Determinant of Impaired Microvascular Energetics in Alzheimer's DiseaseR01AG074489 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI KATAKAM, PRASAD V, MOSTANY, RICARDO · 2021 to 2025
$3.2M
Mitochondrial structure and function in cerebral arteries during diabetes and ischemic stressR01HL148836 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI BUSIJA, DAVID W · 2020 to 2023
$2.6M
Cerebral Microvascular Bioenergetics and Neurovascular CouplingR01NS114286 · NINDS · TULANE UNIVERSITY OF LOUISIANA · PI KATAKAM, PRASAD V, MOSTANY, RICARDO · 2020 to 2024
$2.5M
Endothelial Expression of Neuronal Nitric Oxide SynthaseR01NS094834 · NINDS · TULANE UNIVERSITY OF LOUISIANA · PI KATAKAM, PRASAD V · 2016 to 2019
$1.3M
High throughput assay for mitochondrial respiration in aged brain microvesselsR21AG063345 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BUSIJA, DAVID W · 2019 to 2020
$430k
NHLBI NIH HHS R01 HL093554NHLBI NIH HHS R01 HL148836NIA NIH HHS R01 AG074489NIA NIH HHS R21 AG063345NIGMS NIH HHS U54 GM104940NINDS NIH HHS R01 NS094834NINDS NIH HHS R01 NS114286
6 · The paper itself

Abstract

Mitochondrial numbers and dynamics in brain blood vessels differ between young male and female rats under physiological conditions, but how these differences are affected by stroke is unclear. In males, we found that mitochondrial numbers, possibly due to mitochondrial fission, in large middle cerebral arteries (MCAs) increased following transient middle cerebral artery occlusion (tMCAO). However, mitochondrial effects of stroke on MCAs of female rats have not been studied. To address this disparity, we conducted morphological, biochemical, and functional studies using electron microscopy, Western blot, mitochondrial respiration, and Ca

Indexed as

Ischemic Attack, TransientStrokeAnimalsFemaleMaleMiddle Cerebral ArteryRatsRats, Sprague-Dawleycerebral arteryfemaleischemia-reperfusionmitochondria

Identifiers

PMID36367688
PMCPMC9744641
OpenAlexW4308772754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.