Evidence map›Paper›PMID 36367539›Full record

ReviewThe British journal of radiology2023

The radiological appearances of lung cancer treated with immunotherapy.

Gianluca Milanese, Giulia Mazzaschi, Roberta Eufrasia Ledda, Maurizio Balbi, Sveva Lamorte, Caterina Caminiti, Davide Colombi, Marcello Tiseo, Mario Silva, Nicola Sverzellati

Abstract readReview
In one paragraph

Review in The British journal of radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gianluca MilaneseDepartment of Medicine and Surgery, Unit of Radiological Sciences, University of Parma, Parma, Italy.
Giulia MazzaschiDepartment of Medicine and Surgery, Unit of Medical Oncology, University of Parma, Parma, Italy.
Roberta Eufrasia LeddaDepartment of Medicine and Surgery, Unit of Radiological Sciences, University of Parma, Parma, Italy.
Maurizio BalbiDepartment of Medicine and Surgery, Unit of Radiological Sciences, University of Parma, Parma, Italy.
Sveva LamorteDepartment of Medicine and Surgery, Unit of Radiological Sciences, University of Parma, Parma, Italy.
Caterina CaminitiUnit of Research and Innovation, University Hospital of Parma, Parma, Italy.
Davide ColombiDepartment of Radiological Functions, Radiology Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Marcello TiseoDepartment of Medicine and Surgery, Unit of Medical Oncology, University of Parma, Parma, Italy.
Mario SilvaDepartment of Medicine and Surgery, Unit of Radiological Sciences, University of Parma, Parma, Italy.
Nicola SverzellatiDepartment of Medicine and Surgery, Unit of Radiological Sciences, University of Parma, Parma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapy and prognosis of several solid and hematologic malignancies, including non-small cell lung cancer (NSCLC), have been favourably impacted by the introduction of immune checkpoint inhibitors (ICIs). Their mechanism of action relies on the principle that some cancers can evade immune surveillance by expressing surface inhibitor molecules, known as "immune checkpoints". ICIs aim to conceal tumoural checkpoints on the cell surface and reinvigorate the ability of the host immune system to recognize tumour cells, triggering an antitumoural immune response.In this review, we will focus on the imaging patterns of different responses occurring in patients treated by ICIs. We will also discuss imaging findings of immune-related adverse events (irAEs), along with current and future perspectives of metabolic imaging. Finally, we will explore the role of radiomics in the setting of ICI-treated patients.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsHumansImmunotherapyPrognosisRadiography

Identifiers

PMID36367539
PMCPMC10078868

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.