Evidence map›Paper›PMID 36367436›Full record

ArticleOrganic & biomolecular chemistry2022

Synthesis of push-pull-activated ynol ethers and their evaluation in the bioorthogonal hydroamination reaction.

Dahye Kang, Conrad Wahl, Justin Kim

Open access · greenAbstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. EnamineSynlett : accounts and rapid communications in synthetic organic chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Dahye KangDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. Justin_Kim@dfci.harvard.edu.ORCID 0000-0003-3269-2956
Conrad WahlDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. Justin_Kim@dfci.harvard.edu.
Justin KimDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. Justin_Kim@dfci.harvard.edu.ORCID 0000-0002-4076-2005
Harvard University · USDana-Farber Cancer Institute · US

Funding

Post-Translational Modification of Protein SurfacesDP2ES030448 · NIEHS · DANA-FARBER CANCER INST · PI KIM, JUSTIN · 2018 to 2018
$2.6M
NIEHS NIH HHS 1DP2ES030448NIEHS NIH HHS DP2 ES030448
6 · The paper itself

Abstract

A new class of push-pull-activated alkynes featuring di- and trifluorinated ynol ethers was synthesized. The difluorinated ynol ether exhibited an optimal balance of stability and reactivity, displaying a substantially improved half-life in the presence of aqueous thiols over the previously reported 1-haloalkyne analogs while reacting just as fast in the hydroamination reaction with

Indexed as

EtherEthersAlkynesSulfhydryl CompoundsAlkynesEtherEthersSulfhydryl Compounds

Identifiers

PMID36367436
PMCPMC9769999
OpenAlexW4308773502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.