Evidence map›Paper›PMID 36367334›Full record

ArticleACS synthetic biology2022

A Toolkit for Precise, Multigene Control in

Adam Sanford, Szilvia Kiriakov, Ahmad S Khalil

Abstract read
In one paragraph

Article in ACS synthetic biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Cyanamide-inducible expression of homing nucleaseSynthetic and systems biotechnology · 2024
    Article
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adam SanfordBiological Design Center, Boston University, Boston, Massachusetts 02215, United States.ORCID 0000-0003-4600-1749
Szilvia KiriakovBiological Design Center, Boston University, Boston, Massachusetts 02215, United States.
Ahmad S KhalilBiological Design Center, Boston University, Boston, Massachusetts 02215, United States.ORCID 0000-0002-8214-0546

Funding

ePACE: automation platforms for adaptable and scalable continuous evolution of biomolecules with therapeutic potentialR01EB027793 · NIBIB · BROAD INSTITUTE, INC. · PI Ahmad Samir Khalil, DAVID R LIU · 2019 to 2026
$6.1M
Synthetic toolkit for precision gene expression control and signal processing in mammalian cellsR01EB029483 · NIBIB · HARVARD UNIVERSITY · PI Ahmad Samir Khalil · 2020 to 2026
$5.0M
Synthetic Biology and Biotechnology (SB2) Predoctoral Training ProgramT32GM130546 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHEN, CHRISTOPHER S, KHALIL, AHMAD SAMIR · 2019 to 2023
$1.0M
NIBIB NIH HHS R01 EB027793NIBIB NIH HHS R01 EB029483NIGMS NIH HHS T32 GM130546
6 · The paper itself

Abstract

Systems that allow researchers to precisely control the expression of genes are fundamental to biological research, biotechnology, and synthetic biology. However, few inducible gene expression systems exist that can enable simultaneous multigene control under common nutritionally favorable conditions in the important model organism and chassis

Indexed as

Saccharomyces cerevisiaeSynthetic BiologyAnimalsBiotechnologyGene Regulatory NetworksMammalsPromoter Regions, Geneticgene expression controlinducible promotersMoClo Toolkitnuclear receptorstranscription factorsyeast

Identifiers

PMID36367334
PMCPMC9764411

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.