ArticleThe Journal of pathology2023
Stromal transdifferentiation drives lipomatosis and induces extensive vascular remodeling in the aging human lymph node.
Article in The Journal of pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Lymph node contraction links sex-biased naive CD8Nature aging · 2026Article
- What Do We Know About Immune System Aging from Human and Animal Studies?International journal of molecular sciences · 2026Review
- Comprehensive characterisation of age-related changes in cell subpopulations and tissue structural properties in secondary lymphoid organs.Cell death & disease · 2025Article
- Cancer progression through the lens of age-induced metabolic reprogramming.Nature reviews. Cancer · 2025Review
- Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites.Immunity · 2025Article
- Age-Related Oxidative Stress and Mitochondrial Dysfunction in Lymph Node Stromal Cells Limit the Peripheral T Cell Homeostatic Maintenance and Function.Aging cell · 2025Article
- Review
- An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases.Science China. Life sciences · 2025Review
- Lymph node or lymphoid aggregate? Impact on cancer resection quality, clinical prognosis, and tumor staging.Histology and histopathology · 2025Review
- Follicle-like niches outside the cortex? 3D phase-contrast µCT revealed medullary B cell nodules in mucosa-draining lymph nodes.Frontiers in immunology · 2025Article
- Tips and tricks for a proper radiological assessment of abdominal and pelvic lymph nodes.Abdominal radiology (New York) · 2024Review
- Biomarkers of Aging and Relevant Evaluation Techniques: A Comprehensive Review.Aging and disease · 2024Review
- Editorial: Tumor-draining lymph nodes.Frontiers in immunology · 2024Article
- Distribution of Contractile Structures in a Mouse and Human Lymph Node Associated with Lymph Flow.Acta histochemica et cytochemica · 2023Article
- Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging.Seminars in immunology · 2023Review
- Aging of lymphoid stromal architecture impacts immune responses.Seminars in immunology · 2023Review
- Lessons of Vascular Specialization From Secondary Lymphoid Organ Lymphatic Endothelial Cells.Circulation research · 2023Review
- FRC transplantation restores lymph node conduit defects in laminin α4-deficient mice.JCI insight · 2023Article
- Lymph nodes in health and disease - A pathologist's perspective.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymph node (LN) lipomatosis is a common but rarely discussed phenomenon associated with aging that involves a gradual exchange of the LN parenchyma into adipose tissue. The mechanisms behind these changes and the effects on the LN are unknown. We show that LN lipomatosis starts in the medullary regions of the human LN and link the initiation of lipomatosis to transdifferentiation of LN fibroblasts into adipocytes. The latter is associated with a downregulation of lymphotoxin beta expression. We also show that isolated medullary and CD34
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