Evidence map›Paper›PMID 36367103›Full record

ArticleCirculation research2022

RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function.

Alexander A Akerberg, Michael Trembley, Vincent Butty, Asya Schwertner, Long Zhao, Manu Beerens, Xujie Liu, Mohammed Mahamdeh, Shiaulou Yuan, Laurie Boyer and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Circulation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  5. Review
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  7. Article
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  15. RNA-Binding Proteins in Cardiomyopathies.Journal of cardiovascular development and disease · 2024
    Review
  16. Article
  17. Review
  18. Hypertrophic cardiomyopathy inThe journal of cardiovascular aging · 2024
    Article
  19. RNA binding proteins in cardiovascular development and disease.Current topics in developmental biology · 2024
    Article
  20. Liquid-Liquid Phase Separation Sheds New Light upon Cardiovascular Diseases.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Alexander A AkerbergDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston' MA (A.A.A., M.T., X.L., W.T.P., C.E.B., C.G.B.).ORCID 0000-0001-9385-3739
Michael TrembleyDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston' MA (A.A.A., M.T., X.L., W.T.P., C.E.B., C.G.B.).
Vincent ButtyBioMicroCenter, Department of Biology (V.B.), Massachusetts Institute of Technology, Cambridge' MA.
Asya SchwertnerCardiovascular Research Center, Massachusetts General Hospital, Charlestown' MA (A.A.A., A.S., L.Z., M.M., S.Y., C.N., C.E.B., C.G.B.).ORCID 0000-0002-1899-9401
Long ZhaoHarvard Medical School, Boston, MA (A.A.A., M.T., A.S., L.Z., M.B., X.L., M.M., S.Y., C.M., C.N., W.T.P., C.E.B., C.G.B.).
Manu BeerensHarvard Medical School, Boston, MA (A.A.A., M.T., A.S., L.Z., M.B., X.L., M.M., S.Y., C.M., C.N., W.T.P., C.E.B., C.G.B.).
Xujie LiuDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston' MA (A.A.A., M.T., X.L., W.T.P., C.E.B., C.G.B.).
Mohammed MahamdehCardiovascular Research Center, Massachusetts General Hospital, Charlestown' MA (A.A.A., A.S., L.Z., M.M., S.Y., C.N., C.E.B., C.G.B.).ORCID 0000-0003-3985-6992
Shiaulou YuanCardiovascular Research Center, Massachusetts General Hospital, Charlestown' MA (A.A.A., A.S., L.Z., M.M., S.Y., C.N., C.E.B., C.G.B.).
Laurie BoyerDepartment of Biology (V.B., L.B.), Massachusetts Institute of Technology, Cambridge' MA.
Calum MacRaeHarvard Medical School, Boston, MA (A.A.A., M.T., A.S., L.Z., M.B., X.L., M.M., S.Y., C.M., C.N., W.T.P., C.E.B., C.G.B.).ORCID 0000-0001-5181-2664
Christopher NguyenCardiovascular Research Center, Massachusetts General Hospital, Charlestown' MA (A.A.A., A.S., L.Z., M.M., S.Y., C.N., C.E.B., C.G.B.).ORCID 0000-0003-1475-2329
William T PuDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston' MA (A.A.A., M.T., X.L., W.T.P., C.E.B., C.G.B.).ORCID 0000-0002-4551-8079
Caroline E BurnsDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston' MA (A.A.A., M.T., X.L., W.T.P., C.E.B., C.G.B.).ORCID 0000-0003-1565-7489
C Geoffrey BurnsDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston' MA (A.A.A., M.T., X.L., W.T.P., C.E.B., C.G.B.).ORCID 0000-0002-5812-6621
Boston Children's Hospital · USMACOM (United States) · USBrigham and Women's Hospital · USMassachusetts Institute of Technology · USCleveland Clinic · US

Funding

MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1M
RESEARCH METHODS IN PEDIATRICS HEART DISEASET32HL007572 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Sarah D DE FERRANTI, Jane W. Newburger · 1985 to 2026
$13.0M
Change of InstitutionR35HL135831 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BURNS, CAROLINE E · 2017 to 2023
$4.2M
Optogenetic regulation of intra-ciliary calcium signaling in cardiac situs developmentR01HL165241 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Shiaulou Yuan · 2022 to 2026
$2.7M
Investigating the role of H2A.Z dynamics in regulating cardiac lineage commitmentR01HL140471 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYER, LAURIE A · 2018 to 2021
$2.2M
Modeling thoracic aortic aneurysm in zebrafishR01HL139806 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BURNS, C. GEOFFREY · 2018 to 2021
$1.7M
NHLBI NIH HHS R01 HL139806NHLBI NIH HHS R01 HL140471NHLBI NIH HHS R01 HL165241NHLBI NIH HHS R35 HL135831NHLBI NIH HHS T32 HL007208NHLBI NIH HHS T32 HL007572
6 · The paper itself

Abstract

backgroundRBPs (RNA-binding proteins) perform indispensable functions in the post-transcriptional regulation of gene expression. Numerous RBPs have been implicated in cardiac development or physiology based on gene knockout studies and the identification of pathogenic RBP gene mutations in monogenic heart disorders. The discovery and characterization of additional RBPs performing indispensable functions in the heart will advance basic and translational cardiovascular research.

methodsWe performed a differential expression screen in zebrafish embryos to identify genes enriched in

resultsWe identified 1848 genes enriched in the

conclusionsOur study identifies

Indexed as

CalciumMyocardiumRNA-Binding ProteinsZebrafish ProteinsAnimalsHumansMyocytes, CardiacRepressor ProteinsRNA Splicing FactorsZebrafishCalciumRBPMS2 protein, humanRepressor ProteinsRNA-Binding ProteinsRNA Splicing FactorsZebrafish Proteinsalternative splicinghuman induced pluripotent stem cellsmyocytes, cardiacRNA-binding proteinszebrafish

Identifiers

PMID36367103
PMCPMC9770155
OpenAlexW4308769983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.